Results 171 to 180 of about 1,877,507 (306)

Prognostic Value of the SUVmax-IPI Composite Score on Overall Survival in Metastatic Prostate Cancer. [PDF]

J Clin Med
Türkmen E, Erdoğan AP, Şahbazlar M, Mütevelizade G, Ekinci F.   +4 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Overall survival with beraprost in dogs with IRIS stage 2 chronic kidney disease. [PDF]

Front Vet Sci
Mayumi M, Matsuura T, Sano T.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Segmentation influence on the generalizability of the overall survival models in CT-based oropharyngeal carcinoma patients. [PDF]

Precis Radiat Oncol
Wang Y, Xiao X, Zhang J, Teng X, Li B, Liu K, Cai J, Ge H.   +7 more
europepmc   +1 more source

Metastatic-Free Survival And Overall Survival In Prostate Cancer [PDF]

Value in Health, 2015
Li, T., Thompson, M., Tran, D.
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Regression modelling of overall survival and progression-free survival

, 2020
There are three endpoints commonly used in oncology clinical trials, which are known as overall survival (OS), time to progression (TTP) and progression-free survival (PFS). Recently, PFS has become an important alternative endpoint to OS. In this thesis, both exponential and Weibull distributions are used to investigate the joint model of OS and PFS ...
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Physical Activity Improves Overall Survival in Patients with Hepatocellular Carcinoma. [PDF]

Liver Cancer
Song BG, Lee M, Cho J, Gwak GY, Kang D, Sinn DH.   +5 more
europepmc   +1 more source