Results 101 to 110 of about 3,852 (269)

Study on deformation and failure characteristics of overlying strata with thick loose layers and thin bedrock based on Hoek-Brown criterion

矿业科学学报, 2019
The mechanics parameters of rock mass in Wulanmulun mine are determined on the basis of the experimental data measured in the laboratory and applied Hoek-Brown criterion in this paper.On this basis the failure characteristics of overlying strata caused ...
Li Quansheng, Xu Zhuhe, Zhang Yong, He Wenrui   +3 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Study on the Fracturing Height of Overburden Strata of Coal Face Based on Microseismic Monitoring

, 2011
Coal mining causes the failure of overburden strata and forms caving and water-conducting crack zones,meaning “two regions”.The reliability of the monitoring result of fracturing height of overburden strata is a key factor to define the upper bound of ...
Yong Jie Yang, Min Wang, Xiu Jie Guo, Ming Zhang   +3 more
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Mechanisms and critical criteria of coverd karst collapses under extreme rainfall conditions

Carsologica Sinica
In recent years, the increasing occurrence of covered karst collapses triggered by rainfall conditions has posed a threat to human life and property safety. According to field investigations and statistical data, the triggering factors of karst collapses
Zongyuan PAN, Rui SHU, Jianling DAI, Yan MENG, Mingtang LEI, Long JIA, Xiao MA, Bing BAI   +7 more
doaj   +1 more source

Determination of grouting layer and stability analysis of slurry-resisting overburden in separation grouting [PDF]

The technology of bed separation grouting subsidence reduction is one of the important means of protecting surface buildings and infrastructures in mining areas, the selection of the grouting layer and the integrity of the slurry-resisting overburden ...
Wenbing GUO, Erhu BAI, Longxiang LI, Weiqiang YANG, Dongtao WU   +4 more
core   +1 more source

Microsphere‐Modulated Sensing‐in‐Energy Supercapacitor With Self‐Filtering Ultra‐Large Signal Under High‐g Shocks

Advanced Science, EarlyView.
To overcome severe signal oscillation under extreme impact conditions, this work presents a Sensing‐in‐Energy microdevice which integrates a MEMS inertial structure directly within a supercapacitor electrolyte cavity. Utilizing shock‐driven transient contact and electrolyte damping for signal self‐filtering, it achieves weak‐oscillation, large ...
Zhihao Zheng, Yiqun Wang, Kaiyou Liu, Shancheng Luan, Yajiang Yin, Xiaofeng Wang, Keren Dai, Zheng You   +7 more
wiley   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Experiment research on overburden mining-induced fracture evolution and its fractal characteristics in ascending mining

, 2015
The simulated material model was used to simulate the formation and distribution of overburden fractures induced by ascending mining. The fracture evolution law was revealed. The fractal geometry theory and MATLAB software were applied to analyze fractal
Qian, Deyu, Xiong, Zuqiang, Han, Yafeng, Wang, Cheng, Zhang, Nianchao   +4 more
core   +1 more source