Results 91 to 100 of about 3,852 (269)

Inertia force-displacement method for seismic analysis of shallow buried underground structures

Yantu gongcheng xuebao, 2018
As for the existing practical methods for seismic analysis of underground structures, including seismic coefficient method, free-field racking deformation method, flexible coefficient method, response displacement method, response acceleration method and
DU Xiu-li , XU Zi-gang , XU Cheng-shun , LI Yang
doaj   +1 more source

Dynamic Simulation Research of Overburden Strata Failure Characteristics and Stress Dependence of Metal Mine

Journal of Disaster Research, 2015
This study models the relationship between dynamic stress and dynamic failure characteristics in the extremely complex geological setting of a metal mine. The study also discusses the relationship between dynamic failure characteristics and dynamic stress in the case of mining disturbance of overlying rock mass is also discussed from the micro and ...
Kang Zhao, Zhongqun Guo, Youzhi Zhang
openaire   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

System reliability analysis of bedrock-soil layer slopes subject to seismic action based on the upper bound limit analysis method

Geomatics, Natural Hazards & Risk
Bedrock-soil layer slopes (BSLSs) are widely distributed in nature. The existence of the interface between bedrock and soil layer (IBSL) affects the failure modes of the BSLSs, and the seismic action makes the failure modes more complex.
Qiangshan Yu, Yingbin Zhang, Dejian Li, Qiang Chen, Lirong Lin, Shihao Zhang, Wentao Jia   +6 more
doaj   +1 more source

Integrative solution of stress evolution in overburden roof strata during the coal seam mining by application of complex variable functions methodology

Rock Mechanics Bulletin
Large-scale roof collapse is a major dynamic hazard threatening the safe coal mine operations. Understanding the deformation and failure characteristics of overburden rock strata, as well as deciphering the stress evolution mechanism of overburden rock ...
Yinkai Li, Hongwei Wang, Zhanbin Zhu, Daixin Deng, Naisheng Jiang   +4 more
doaj   +1 more source

Using the Magnetotelluric Method for Detecting Aquifer Failure Characteristics under High-Intensity Mining of Thick Coal Seams

Energies, 2019
In the ecologically fragile mining area of northwest China, high-intensity mining has seriously affected the aquifer and surface eco-environment. In order to better implement water-preserved mining in ecologically fragile areas, the aquifer failure ...
Erhu Bai, Wenbing Guo, Dongsheng Zhang, Yi Tan, Mingjie Guo, Gaobo Zhao   +5 more
doaj   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Research on deformation and failure characteristics of overburden and surface in high-intensity mining of Caojiatan Coal Mine

Meikuang Anquan
Under high-intensity mining conditions, the structural response of overburden is severe, significantly affecting the safety of surface structures. Taking the 122104 super-large mining height working face of Caojiatan Coal Mine in the Yushen Mining Area ...
Zhaolai HUA, Yang LYU, Shengxiang GAO, Zehui WU, Xufeng WANG, Lei ZHANG   +5 more
doaj   +1 more source