Results 71 to 80 of about 3,852 (269)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Method to Calculate Mining-Induced Fracture Based on the Movement and Deformation of Overburden Strata

, 2021
Mining-induced fracture of overburden strata is intimately related to underground water disasters in coal mining. In this work, we develop an analytical model that uses the probability integral method to calculate the subsidence of the subsurface and the
Guo-sheng Xu, De-hai Li, Hui-gui Li, Yan-bin Zhang   +3 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Study on evolution law of overburden stress under different strip coal pillar widths

Meikuang Anquan
The plastic failure of strip-style goaf areas due to weathering, groundwater erosion, and overburden load is one of the main causes of geological disasters in the surrounding rocks of goaf areas. Revealing the stress evolution laws under the expansion of
Shenghu LUO, Zhihui MENG, Chengyang TIAN, Zhuangzhuang YAN, Jiabo GAO, Duanyang XIA   +5 more
doaj   +1 more source

Overburden Damage Degree-Based Optimization of High-Intensity Mining Parameters and Engineering Practices in China’s Western Mining Area

Geofluids, 2020
China’s western mining area is an arid and semiarid area with a fragile ecological environment, and the high-intensity mining activities aggravate ecological damage.
Xiang He, Cun Zhang, Penghua Han
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Geomechanics and Rock Physics of Anisotropic Overburden Shales

, 2023
Shales, with their diverse composition and complex properties, present an interesting research subject and a challenging material to work with. As they constitute a significant portion of the overburden in most currently operational subsurface storage ...
Duda, Marcin Ireneusz
core   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Deformation prediction analysis of sandstone coal mine goaf based on discrete element method and probability integration method

Frontiers in Materials
Accurate prediction of goaf settlement is essential for evaluating surface movement and deformation and for understanding overburden failure mechanisms in sandstone coal mine goafs.
Gao Ruonan, Chen Xi, Wang Yuchen, Liu Gen, Li Jin   +4 more
doaj   +1 more source