Results 51 to 60 of about 3,852 (269)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Study on Space–Time Evolution Law and Mechanism of Instability Failure of Deep High-Stress Overburden Rock

, 2023
In order to explore the fracture law and structural evolution characteristics of overlying strata in deep high-stress mining, according to the geometric characteristics and mechanical causes of overlying strata in different mining stages of the stope ...
Fuxu Hao, Wengang Liu, Tian Jiang, Qiao Zhang, Youyu Wei, Xinfeng Wang   +5 more
core   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Deformation and Failure Model Test of Binary Structure Anti-dip Excavation Slope under the Action of Seismic Load

工程科学与技术, 2012
:The slope, where Wangjiaping landslide was located in Longmenshan Town, Pengzhou City, was selected as a typical example of binary structure anti-dip slope with excavation failure in this study, and indoor physical model tests were carried out on ...
afayou
doaj  

Overburden structural evolution and mechanism of strong ground pressure in ultra-large mining height longwall face with thick hard roof

Meitan xuebao
Ultra-large mining height faces with multiple thick and hard strata (MTHS) exhibit highly complex overburden structural evolution, intense support loading, and frequent dynamic events, posing serious challenges to roof stability and safe, efficient ...
Jianzhong LI, Fuqiang GAO, Jinfu LOU, Zhizeng HUANG, Zhen ZHANG, Jinhong YANG, Chaodong XI, Pengjie LI, Feixiang LE   +8 more
doaj   +1 more source

Study on mechanism of overburden rock failure during coal mining with shallow depth and thin bedrock

, 2011
The paper studies the mechanism of overburden rock failure of Hongshuliang mine of Junger coalfield in Inner Mongolia. With overlying bedrock of shallow depth and thin thickness, after mining the first-extracting coal seam, the instability of overlying ...
Hui-Qing, Lian
core   +1 more source

Characteristics of Overburden and Ground Failure in Mining of Shallow Buried Thick Coal Seams under Thick Aeolian Sand

, 2022
Mining can lead to overburden failure and ground damage, which are more severe in mining shallow buried thick coal seams (SBTCS) under thick aeolian sand (TAS).
Junjie Chen, Guangchun Liu, Youfeng Zou, Wenzhi Zhang   +3 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source