Results 41 to 50 of about 4,032 (249)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Mechanism of dynamic load of longwall mining under shallow room mining goaf

open access: yesYantu gongcheng xuebao, 2019
In order to explore the control mechanism of pressure appearing in the lower coal seam of shallow-buried coal bed with room mining goaf, to reduce the dynamic pressure of the working face through the room mining goaf, and to mitigate the risk caused by ...
HUO Bing-jie 1, JING Xue-dong 1, FAN Zhang-lei 1, XIE Wei 2, DUAN Zhi-hua 1, XIE Zhen-hua 1
doaj   +1 more source

Subsidence Prediction of Overburden Strata and Surface Based on the Voussoir Beam Structure Theory [PDF]

open access: yesAdvances in Civil Engineering, 2018
The hard and stiff strata (key strata) bear the overburden load in the form of a voussoir beam structure (VBS) after break. The VBS affects both the surface subsidence and the stope underground pressure. Therefore, the reasonable method to predict the surface subsidence is based on the whole subsidence formulae of the VBS.
Changchun He, Jialin Xu
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Disaster mechanism induced by overburden structure and control techniques for close-distance coal seam group

open access: yesMeitan xuebao
Compared to single-seam mining, the close-distance coal seam group is strongly influenced by the movement of overburden structure resulting from upper seam mining.
Yunliang TAN   +6 more
doaj   +1 more source

Subsidence prediction of overburden strata and ground surface in shallow coal seam mining

open access: yesScientific Reports, 2021
Shallow coal seam with thick soil layer is widely reserved in the Jurassic Coalfield, Western China, mining-induced subsidence represents complex characteristics.
Jian Cao, Qingxiang Huang, Lingfei Guo
doaj   +1 more source

Study on evolution law of overburden structure based on microseismic distribution characteristics

open access: yesMeikuang Anquan, 2023
There are several key layers with large thickness above the 402 working face of wide coal pillar in Hongqinghe Coal Mine. The existence of key layers will significantly increase the peak value of abutment pressure and its influence range. Based on the microseismic distribution characteristics of 402 working face are analyzed based on microseismic ...
Xiang MA   +7 more
openaire   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano   +11 more
wiley   +1 more source

Research on Strata Movement Control in Deep Composite Lithologic Gangue Backfill Mining of Super-Thick and Weak Cementation Overburden Based on PFC–FLAC Coupling Simulation

open access: yesAdvances in Civil Engineering
In order to alleviate geological disasters such as rock burst, mine earthquake, and surface subsidence and realize the coordinated development of coal resources safe mining and environmental protection in Ordos coalfield, this article proposes a local ...
Yonglei Li   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy