Results 61 to 70 of about 47,624 (295)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Research on Strata Movement Control in Deep Composite Lithologic Gangue Backfill Mining of Super-Thick and Weak Cementation Overburden Based on PFC–FLAC Coupling Simulation

Advances in Civil Engineering
In order to alleviate geological disasters such as rock burst, mine earthquake, and surface subsidence and realize the coordinated development of coal resources safe mining and environmental protection in Ordos coalfield, this article proposes a local ...
Yonglei Li, Jiangning Gan, Guojian Zhang, Zhiyong Liu, Guangli Guo, Baode Guo, Shuo Sun   +6 more
doaj   +1 more source

Mechanism of dynamic load of longwall mining under shallow room mining goaf

Yantu gongcheng xuebao, 2019
In order to explore the control mechanism of pressure appearing in the lower coal seam of shallow-buried coal bed with room mining goaf, to reduce the dynamic pressure of the working face through the room mining goaf, and to mitigate the risk caused by ...
HUO Bing-jie 1, JING Xue-dong 1, FAN Zhang-lei 1, XIE Wei 2, DUAN Zhi-hua 1, XIE Zhen-hua 1
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

The Miocene Bükkábrány Fossil Forest in Hungary – field observations and project outline [PDF]

, 2008
The oldest, standing forest preserved as wood has been found at Bükkábrány, Hungary. An open-pit mine working Upper Miocene (Pannonian) lignite revealed sixteen stumps, 1.8 to 3.6 m diameter at base, preserved up to 6 m height, standing on top of the ...
Kázmér, Miklós
core  

Optimization of position of the cyclical-and-continuous method complexes when cleaning-up the deep iron ore quarries [PDF]

, 2019
Purpose. An algorithm development for calculating the optimum depth for cyclical-and-continuous method schemes introduction when cleaning-up the deep iron ore quarries. Methods. When developing an algorithm for calculating the optimum depth for cyclical-
Adamchuk, A, Kaluzhnyi, Ye, Kuzmenko, S, Moldabayev, S, Shustov, O, Toktarov, A   +5 more
core   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Design and loading of dragline buckets [PDF]

, 1999
Draglines are an expensive and essential part of open cut coal mining. Small improvements in performance can produce substantial savings. The design of the bucket and the way in which it fills with overburden are very important to the overall dragline ...
Carnie, S.
core