Results 31 to 40 of about 26,263 (305)

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Rgbp: An R Package for Gaussian, Poisson, and Binomial Random Effects Models with Frequency Coverage Evaluations

Journal of Statistical Software, 2017
Rgbp is an R package that provides estimates and verifiable confidence intervals for random effects in two-level conjugate hierarchical models for overdispersed Gaussian, Poisson, and binomial data.
Hyungsuk Tak, Joseph Kelly, Carl Morris
doaj   +1 more source

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The impact of presumptive coverage policies for work‐related mental health disorders has not been extensively studied to date. Using data from the Association of Workers’ Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensated mental health conditions, and to explore the association ...
Quentin Durand‐Moreau, Alexis Descatha, Anil Adisesh, Peter Smith   +3 more
wiley   +1 more source

Scaling limits for infinite-server systems in a random environment

Stochastic Systems, 2017
This paper studies the effect of an overdispersed arrival process on the performance of an infinite-server system. In our setup, a random environment is modeled by drawing an arrival rate Λ from a given distribution every Δ time units, yielding an i.i.d.
Mariska Heemskerk, Johan van Leeuwaarden, Michel Mandjes   +2 more
doaj   +1 more source

General Practice Utilisation for Adults With Neurological Disability Who Are National Disability Insurance Scheme Participants in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Most adults with neurological disability rely on general practitioners for managing and preventing health complications. This study analysed patterns of general practice service utilisation among National Disability Insurance Scheme (NDIS) participants with neurological disability and compared these with people who are not NDIS participants ...
Stacey Oliver, Robin A. Ramme, Avinash Kondiboyina, Karina Gardner, Adam McLeod, Stephen Weeding, Christopher Pearce, Jacinta Douglas, Di Winkler   +8 more
wiley   +1 more source

CONWAY-MAXWELL POISSON REGRESSION MODELING OF INFANT MORTALITY IN SOUTH SULAWESI

Media Statistika
Overdispersion is a common problem in count data that can lead to inaccurate parameter estimates in Poisson regression models. Quasi-Poisson and negative binomial regressions are often used to address overdispersion but have limitations, especially with ...
Oktaviana Oktaviana, Wahidah Sanusi, Aswi Aswi, Sukarna Sukarna, Serifat Adedamola Folorunso   +4 more
doaj   +1 more source

Practice‐level variation in potentially inappropriate prescribing in middle‐aged adults: A repeated cross‐sectional study in South London general practice

British Journal of Clinical Pharmacology, EarlyView.
Aim To quantify between‐practice variation in potentially inappropriate prescribing (PIP) among middle‐aged adults (45–64 years) in UK general practice, and to identify patient‐ and practice‐level characteristics associated with PIP. Methods Repeated cross‐sectional study using linked data from the Lambeth DataNet and Quality Outcomes Framework across ...
Ryan Jayesinghe, Amandeep Khatter, Stevo Durbaba, Mark Ashworth, Benjamin Jacob, Frank Moriarty, Patrick Redmond   +6 more
wiley   +1 more source

Decomposing niche components reveals simultaneous effects of opposite deterministic processes structuring alpine small mammal assembly

Frontiers in Ecology and Evolution, 2023
IntroductionSpecies distribution in alpine areas is constrained by multiple abiotic and biotic stressors. This leads to discrepant assembly patterns between different locations and study objects as opposite niche-based processes—limiting similarity and ...
Wen-Yu Song, Wen-Yu Song, Kenneth Otieno Onditi, Kenneth Otieno Onditi, Xue-You Li, Zhong-Zheng Chen, Zhong-Zheng Chen, Shui-Wang He, Quan Li, Xue-Long Jiang   +9 more
doaj   +1 more source

Testing for zero-modification in count regression models [PDF]

, 2006
Count data often exhibit overdispersion and/or require an adjustment for zero outcomes with respect to a Poisson model. Zero-modified Poisson (ZMP) and zero-modified generalized Poisson (ZMGP) regression models are useful classes of models for such ...
Min, Aleksey, Czado, Claudia
core   +1 more source