Results 211 to 220 of about 1,514,926 (296)

Assessing User Engagement With an Interactive Mapping Dashboard for Overdose Prevention Informed by Predictive Modeling in Rhode Island. [PDF]

J Public Health Manag Pract
Skinner A, Neill DB, Allen B, Krieger M, Gray JY, Pratty C, Macmadu A, Goedel WC, Samuels EA, Samuels EA, Ahern J, Cerdá M, Marshall BDL.   +12 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Trends and characteristics during 17 years of naloxone distribution and administration through an overdose prevention program in Pittsburgh, Pennsylvania. [PDF]

PLoS One
Dasgupta N, Bell A, Visnich M, Doe-Simkins M, Wheeler E, Sibley AL, Nocera M, Seitz AE, Chang D, Barlow S, Dezman ZDW, McAninch JK.   +11 more
europepmc   +1 more source

Honouring Hardship and Fun: Reflecting on Homeless Children's Experiences in Shelter

Children &Society, EarlyView.
ABSTRACT In our research with children living in a homeless shelter with their families in Southern Ontario, Canada, we navigated discrepancies between the challenges and hardships in our participants' lives and the fun, positive nature of many of our day‐to‐day interactions with them.
Rebecca Raby, Christine Tardif‐Williams, Erika Alegria, Frederick Oppong, Luiza Mattos Jobim da Costa   +4 more
wiley   +1 more source

Witnessed overdose history and response among overdose survivors who use non-prescribed opioids in an overdose prevention trial. [PDF]

Addict Behav
McCann NC, Yan S, McMahan VM, Rich ZC, Pope E, Rolles A, Brennan S, Marti XL, Kosakowski S, Matheson T, Coffin PO, Walley AY.   +11 more
europepmc   +1 more source

Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An Experimental Pilot In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives Given the proposed bioactive role of collagen membranes, we aimed to evaluate whether the perforation size of titanium‐reinforced dPTFE membranes, with or without an additional collagen membrane, influences outcomes of vertical alveolar ridge augmentation (VARA).
Istvan A. Urban, Sándor Farkasdi, Muhammad H. A. Saleh, Monica Lopez, Fernando Muñoz, Gabor Varga, Mauricio G. Araujo, Fabio Vignoletti   +7 more
wiley   +1 more source

Use of low-threshold naloxone boxes for opioid overdose prevention in a Midwestern US State: a public health program evaluation. [PDF]

Harm Reduct J
Lynch PS, Gamalski L, Roys V, Albers A, Burk K, Durán S, Facente SN.   +6 more
europepmc   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Under‐ and overdosing insulin in the hospital: A retrospective cohort study of dose deviation and patient outcomes

Diabetic Medicine, EarlyView.
Abstract Aims Glycaemic abnormalities during hospitalization are common and linked to morbidity and mortality, yet little is known about how deviations from guideline‐recommended insulin dosing affect outcomes. The aim of this study is to examine whether deviation from an expected insulin dose in non‐critically ill hospitalized adults with type 2 ...
Hussein Zaitoon, Sher Matsri, Shira Nagler, Matteo M. Lalovich, Ralph A. DeFronzo, Eugene Feigin   +5 more
wiley   +1 more source

Predictors of Retention in a Clinical Trial of a Fentanyl Overdose Prevention Intervention: Implications for Supporting Participants' Retention in Harm Reduction Research. [PDF]

Subst Use Misuse
Goldman JE, Park CJ, Shaw LC, Noguchi JE, Hadland SE, Marshall BDL.   +5 more
europepmc   +1 more source