Results 211 to 220 of about 1,616,124 (301)

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Recruiting a National Sample of First Response Agencies to Participate in an Overdose Prevention Research Project: Randomized Controlled Trial and Feasibility Study. [PDF]

JMIR Form Res
Agley J, Henderson C, Nair M, Seo DC, Parker M, Golzarri-Arroyo L, Dickinson S, Tidd D.   +7 more
europepmc   +1 more source

Honouring Hardship and Fun: Reflecting on Homeless Children's Experiences in Shelter

Children &Society, EarlyView.
ABSTRACT In our research with children living in a homeless shelter with their families in Southern Ontario, Canada, we navigated discrepancies between the challenges and hardships in our participants' lives and the fun, positive nature of many of our day‐to‐day interactions with them.
Rebecca Raby, Christine Tardif‐Williams, Erika Alegria, Frederick Oppong, Luiza Mattos Jobim da Costa   +4 more
wiley   +1 more source

Opioid withdrawal as a barrier to harm reduction: Examining how overdose prevention behaviors are affected by withdrawal. [PDF]

Drug Alcohol Depend
Yi G, Dayton L, Scott-Wallace A, Davey-Rothwell M, Falade-Nwulia S, Latkin C.   +5 more
europepmc   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Strategies to Facilitate Interorganizational Collaboration in County-Level Opioid Overdose Prevention and Response: A Qualitative Analysis. [PDF]

Int J Environ Res Public Health
Dickson-Gomez J, Krechel S, Ohlrich J, Hernandez-Meier J, Kostelac C.   +4 more
europepmc   +1 more source

A descriptive study of drug overdose epidemics, overdose prevention efforts, and opioid settlement fund distribution across six states. [PDF]

Int J Drug Policy
Li Z, Chiddawar TV, Shaw LC, Dennis A, Lieberman A, Kingsepp A, Trinidad AJ, Tuazon E, Welch AE, Chatterjee A, Schackman BR, Enns EA, Walley AY, Green TC, Wagner KD, Winograd RP, Behrends CN, Crable EL, Marshall BDL, Zang X.   +19 more
europepmc   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Response to Crockford et al.: Healthcare utilization and mortality after overdose prevention site closure: A linked cohort analysis using segmented difference-in-differences time series. [PDF]

Addiction
Day N, Vik S, Tanguay R, Mathew N, Bahji A.   +4 more
europepmc   +1 more source