Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation. [PDF]
Wang K +11 more
europepmc +1 more source
Astrocytic PDE7B Drives Blood-Brain Barrier Breakdown via Extracellular Vesicles in Demyelinating Disease. [PDF]
Duan J +7 more
europepmc +1 more source
GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27-mediated ACLY Ubiquitination and Lipid Metabolism. [PDF]
Xiong KP +11 more
europepmc +1 more source
NAT10 promotes proliferation, invasion, and epithelial-mesenchymal transition in hepatocellular carcinoma through α-tubulin acetylation. [PDF]
Yu H +10 more
europepmc +1 more source
PRRSV N protein antagonizes host antiviral immune responses by upregulating HSPA1B to induce autophagic degradation of Fos-related antigen 1. [PDF]
Liu X +11 more
europepmc +1 more source
ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response in C. elegans. [PDF]
Guan L +5 more
europepmc +1 more source
DUSP1 Inhibits Mechanotransduction and MAPK Signalling to Alleviate Myocardial Cell Hypertrophy. [PDF]
Zhong X +5 more
europepmc +1 more source
THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A. [PDF]
Liu J +15 more
europepmc +1 more source
A Mouse Model for the Overexpression of Methyltransferases
One of the epigenetic mechanisms by which gene expression is regulated is the methylation of DNA. Erroneous DNA methylation can cause a vast spectrum of diseases. A mouse model was created in this study to investigate whether the overexpression of the somatic form of Dnmt1, Dnmt1s, is sufficient to cause erroneous methylation and disease.
openaire +2 more sources

