Results 211 to 220 of about 426,067 (292)

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Critical evaluation of factorial experimental designs and temporal confounding in comparative analysis of dietary vs parenteral iron administration effects on cortical and trabecular bone parameters. [PDF]

JBMR Plus
Zaheer MH, Shahnawaz Z, Zaheer H.
europepmc   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

Systemic Metabolomic Remodeling in Pressure Overload-Induced Heart Failure Indicates Modulation of a Gut-Liver-Heart Axis by the Adiponectin Receptor Agonist ALY688. [PDF]

Metabolites
Lei Y, Li B, Gosse T, Cho S, Sung HK, Chen J, Sweeney G.   +6 more
europepmc   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Removal of Methylene Blue and Congo Red Dyes Using Sustainable and Eco‐Friendly Bioadsorbents: A Review

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The continuous increasing discharge of synthetic dyes into aquatic systems seems to be an important environmental and health risk due to their high toxicity and resistance to biodegradation. Among these dyes, methylene blue (MB) and Congo red (CR) are widely used in textile and industrial applications, necessitating sustainable and efficient ...
Avanish Kumar, Ashish Kapoor, Dan Bahadur Pal   +2 more
wiley   +1 more source

Copper-Induced Cell Death in Renal Diseases: Molecular Mechanisms and Therapeutic Implications. [PDF]

Drug Des Devel Ther
Lv D, Yu Y.
europepmc   +1 more source

Trabecular bone ontogeny of the human talus

The Anatomical Record, EarlyView.
Abstract Studies of trabecular ontogeny may provide insight into the factors that drive healthy bone development. There is a growing understanding of how the juvenile skeleton responds to these influences; however, gaps in our knowledge remain. This study aims to identify ontogenetic trabecular patterns and regional changes during development within ...
Rebecca A. G. Reid, Catriona Davies, Craig Cunningham   +2 more
wiley   +1 more source

Health information anxiety in social media users during public health emergencies: A qualitative comparative analysis using attribution theory. [PDF]

PLoS One
Wenchang X, Xuanhui Y, Qun Z, Xiao C.
europepmc   +1 more source