Results 31 to 40 of about 260,401 (265)

Firepower-target assignment method based on deep reinforcement learning algorithm [PDF]

Zhihui kongzhi yu fangzhen
Aiming at the characteristics of large solution space, discrete, dynamic and nonlinear of firepower-target assignment problem, this paper proposes a deep reinforcement learning algorithm based on DQN.
LI Weiguang, CHEN Dong
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oxygen overload

eLife, 2021
A structure that helps algae photosynthesize when carbon dioxide levels are low may also play a role during hyperoxia conditions.
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Physiological Responses in Trail Runners during a Maximal Test with Different Weighted-Vest Loads

Sports
During some trail running races, athletes have to carry hydration support, food, and technical and safety equipment, which generates an additional load that must be mobilized during the race.
Germán Jiménez-Redondo, Bruno Castro-Frecha, Francisco Javier Martínez-Noguera, Pedro E. Alcaraz, Cristian Marín-Pagán   +4 more
doaj   +1 more source

Does fibroblast growth factor 23 correlates with volume status in hemodialysis patients? [PDF]

Journal of Nephropathology, 2019
Introduction: Volume overload is a known risk factor for cardiovascular disease and stroke in hemodialysis patients. The use of fibroblast growth factor 23 (FGF23) as a volume overload marker has been validated in multiple studies.
Farzanehsadat Minoo, Azam Alamdari, Hamed Karimi   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Implementasi Load Balancing Pada Web Server Menggunakan Nginx

Jurnal Teknologi dan Manajemen Informatika, 2020
Kebutuhan internet mempengaruhi pengunjung website semakin meningkat dan membuat beban traffic meningkat pada server, semakin banyak jumlah traffic ke server bisa menyebabkan web server menjadi down, jika digunakan dengan jumlah berlebih (overload ...
Fahmi Apriliansyah, Iskandar Fitri, Agus Iskandar   +2 more
doaj   +1 more source