Results 41 to 50 of about 383,999 (305)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Research on the Construction Method and Key Technologies of Unexploded Submunition Image Dataset [PDF]
Hangkong bingqiWith the rapid development and application of computer technology and machine vision technology, the exploration of unexploded submunition search technology based on “artificial intelligence +” model has received extensive attention.
Yan Xiaowei, Chen Dong
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Morphological adaptations of quadriceps femoris muscle in subjects trained with traditional training and subjects trained with eccentric overload on the leg press [PDF]
, 2022 openLa seguente trattazione verterà sullo studio degli adattamenti dati dall’allenamento con overload eccentrico studiati nel periodo tra Aprile ’22 e Luglio ’22 durante una sperimentazione condotta da un gruppo di studenti del terzo anno di Scienze ...
FERRARA, DAVIDE
core
Firepower-target assignment method based on deep reinforcement learning algorithm [PDF]
Zhihui kongzhi yu fangzhenAiming at the characteristics of large solution space, discrete, dynamic and nonlinear of firepower-target assignment problem, this paper proposes a deep reinforcement learning algorithm based on DQN.
LI Weiguang, CHEN Dong
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Effectiveness of Eccentric Overload Training in Basketball Players: A Systematic Review [PDF]
, 2023 Several studies have confirmed the efficacy of flywheel eccentric overload training in order to improve or increase muscle volume and strength, as well as several performance-related fitness attributes, but to date, there are no studies that have ...
Marko Stojanovic +9 more
core +1 more source
Estudi de les mutacions dels exons 2 i 4 del gen HFE en pacients amb porfiria cutània tarda esporàdica [PDF]
, 2006 [cat] La Porfíria Cutània Tarda (PCT) és una malaltia metabòlica que afecta a la pell i al fetge i que és desencadenada per la interacció de múltiples factors que inclouen l´herència, l´alcohol, el VHC, els estrògens i alguns agents tòxics, entre d ...
Toll Abelló, Agustí
core +5 more sources
A Muscle Load Feedback Application for Strength Training: A Proof-of-Concept Study
Sports, 2023 Muscle overload injuries in strength training might be prevented by providing personalized feedback about muscle load during a workout. In the present study, a new muscle load feedback application, which monitors and visualizes the loading of specific ...
Lisa Noteboom +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source