Results 121 to 130 of about 278,156 (310)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Backsliding under contested oversight
Political Science Research and MethodsCitizens do not directly observe democratic backsliding and, as a result, may hesitate to respond to subversion. We develop a model of third-party oversight bodies, such as the media or courts, that detect and assess actions that may be subversive to ...
Robert Gulotty, Zhaotian Luo
doaj +1 more source
, 2010 December report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the U.S. Treasury's foreclosure prevention effort, the Home Affordable Modification Program (HAMP).
United States. Congressional Oversight Panel.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
SC Education Oversight Committee [PDF]
, 2011 This brochure describes the SC Education Oversight Committee and the things that it does in reporting facts, promoting progress and measuring change in the South Carolina educational ...
South Carolina Education Oversight Committee
core +1 more source
, 2010 October report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the use of private contractors in the implementation of the U.S. Treasury's Troubled Asset Relief Program (TARP)
United States. Congressional Oversight Panel.
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Citizen Brief: Modernizing the Oversight of the Health Workforce in Ontario [PDF]
, 2017 An assessment of what is known about problems related to the oversight of the health workforce in Ontario, options for addressing these problems, and key implementation considerations.
Moat, KA, Waddell, K, Lavis, JN
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2008 July report of the U.S. Congressional Oversight Panel describing their activities and findings regarding the repayment of financial assistance that banks received from the U.S. Treasury through the Troubled Asset Relief Program (TARP)
United States. Congressional Oversight Panel.
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