Results 81 to 90 of about 955,210 (402)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

An ecological systems approach to examining risk factors for early childhood overweight: findings from the UK Millennium Cohort Study [PDF]

, 2009
Objective: To use an ecological systems approach to examine individual-, family-, community- and area-level risk factors for overweight (including obesity) in 3-year-old children. Methods: A prospective nationally representative cohort study conducted in
Cole, T.J., Hawkins, S.S., Law, C., Millennium Cohort Study Child Health Group, The   +3 more
core  

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Obesity consequences from the people's perspective living in Kurdish regions of Iran: A qualitative content analysis

Journal of Education and Health Promotion, 2019
BACKGROUND: Overweight and obesity are one of the most public health problems in the world. Considering obesity prevalence and its widespread health, economic, psychological, and social consequences, this study aimed to explain the consequences of ...
Seyed Fahim Irandoost, Mohammad Hosein Taghdisi, Tahereh Dehdari, Bahman Bayangani, Nammam Ali Azadi   +4 more
doaj   +1 more source

Peer Victimization in Overweight Adolescents and Its Effect on Their Self-Esteem and Peer Difficulties [PDF]

, 2019
This study has three objectives: to examine whether adolescents who perceive themselves as overweight differ from others in terms of offline victimization at school, cybervictimization, self-esteem, and difficulties relating to peers; to examine the ...
Núñez, Andrea, Núñez, José Carlos, Pérez Fuentes, María Del Carmen, Álvarez García, David   +3 more
core   +1 more source

Multilevel correlates of household anthropometric typologies in Colombian mothers and their infants [PDF]

, 2018
Background. The aim of this study was to establish the association of maternal, family, and contextual correlates of anthropometric typologies at the household level in Colombia using 2005 Demographic Health Survey (DHS/ENDS) data.Methods.
Brownson, R. C, Gomez, L. F, Haire-Joshu, D., Iannotti, L., Parra, D. C, Sebert Kuhlmann, A. K   +5 more
core   +2 more sources

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

PLoS Medicine, 2019
Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the ...
E. Voerman, S. Santos, Bernadeta Patro Golab, P. Amiano, F. Ballester, H. Barros, A. Bergström, M. Charles, L. Chatzi, C. Chevrier, G. Chrousos, E. Corpeleijn, N. Costet, S. Crozier, G. Devereux, M. Eggesbø, Sandra Ekström, M. Fantini, S. Farchi, F. Forastiere, V. Georgiu, K. Godfrey, D. Gori, V. Grote, W. Hanke, I. Hertz-Picciotto, B. Heude, D. Hryhorczuk, Rae-Chi Huang, H. Inskip, N. Iszatt, A. Karvonen, L. Kenny, B. Koletzko, L. K. Küpers, H. Lagström, I. Lehmann, P. Magnus, R. Majewska, J. Mäkelä, Y. Manios, F. Mcauliffe, S. McDonald, J. Mehegan, M. Mommers, C. S. Morgen, Trevor A. Mori, G. Moschonis, D. Murray, C. N. Chaoimh, E. Nøhr, A. Nybo Andersen, E. Oken, A. Oostvogels, A. Pac, E. Papadopoulou, J. Pekkanen, C. Pizzi, K. Polańska, D. Porta, L. Richiardi, S. Rifas-Shiman, L. Ronfani, A. Santos, M. Standl, C. Stoltenberg, E. Thiering, C. Thijs, M. Torrent, S. Tough, T. Trnovec, S. Turner, L. van Rossem, A. von Berg, M. Vrijheid, T. Vrijkotte, J. West, A. Wijga, John Wright, O. Zvinchuk, T. Sørensen, D. Lawlor, R. Gaillard, V. Jaddoe   +83 more
semanticscholar   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Population Trends & Obesity Patterns in the Philippines: A Window to the Obesity Epidemic in the Asia-Oceania Region

Journal of the ASEAN Federation of Endocrine Societies, 2014
Dr. Lee Kaplan, in his lecture at the recently concluded Postgraduate Course in Endocrinology (Harvard Medical School, Boston, MA, USA) described obesity as a very common and growing problem, with a complex physiology and clinically heterogenous picture,
Augusto D. Litonjua
doaj  

Excesso de peso e inatividade física em crianças moradoras de favelas na região metropolitana do Recife, PE Overweight and physical inactivity in children living in favelas in the metropolitan region of Recife, Brazil

Jornal de Pediatria, 2009
OBJETIVO: Verificar a frequência de excesso de peso em crianças de favelas na cidade do Recife, PE, e sua associação com inatividade física. MÉTODOS: Foi realizado estudo transversal em duas favelas do Recife (Fragoso e Caranguejo), com população total ...
João Guilherme Bezerra Alves, Pollyanna P. Siqueira, José Natal Figueiroa   +2 more
doaj   +1 more source