Results 101 to 110 of about 181,054 (296)

Quantitative electroencephalographic measures during postmalarial epileptogenesis

open access: yesEpilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi   +14 more
wiley   +1 more source

Pathogenic PPP2R5D variants disrupt neuronal development and neurite outgrowth in patient-derived neurons that are reversed by allele-specific knockdown

open access: yesHGG Advances
Summary: A significant barrier to the treatment of neurodevelopmental disorders (NDDs) is a limited understanding of disease mechanisms. Heterozygous missense variants in PPP2R5D cause Houge-Janssens syndrome 1, a rare NDD characterized by macrocephaly ...
Randee E. Young   +6 more
doaj   +1 more source

Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development

open access: yesEpilepsia, EarlyView.
Abstract Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options has reduced baseline seizure burden, with a risk of excluding a proportion of patients from trials. Although
Stéphane Auvin, Jacqueline French
wiley   +1 more source

Naturalis Historia, Reconstructed [PDF]

open access: yes, 2013
When Pliny the Elder wrote Naturalis Historia around 70 A.D., the idea of natural history contained and connected biology, geology, and mineralogy with the history of painting and sculpture. Art was an extension of the natural world as its materials were
Briland, Sarah
core   +1 more source

Status epilepticus: Updates on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Bark and Leaf Essential Oil of , California Bay Laurel, from Oregon

open access: yesNatural Product Communications, 2007
The bark and leaf essential oil of Umbellularia californica (Hook. & Arn.) Nutt. from west central Oregon, USA, was isolated by steam distillation and the chemical composition analyzed by GC-FID and GC-MS.
Rick G. Kelsey   +2 more
doaj   +1 more source

Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Expanded indications, diagnostic tools, and treatment options have transformed the landscape of modern pediatric epilepsy surgery. Published real‐world experiences from large surgical cohorts are still needed. To close this gap, we evaluated access, indications, treatment, and outcomes in a contemporary pediatric epilepsy surgery ...
John R. McLaren   +12 more
wiley   +1 more source

KCNQ2 neonatal epilepsy: Impact of prompt diagnosis and treatment, and early predictors of outcome severity

open access: yesEpilepsia Open, EarlyView.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective To determine whether prompt genetic diagnosis in children with KCNQ2 neonatal epilepsy enabling targeted therapy is associated with improved outcomes, and identify early predictors of developmental outcomes.
Trupti Jadhav   +17 more
wiley   +1 more source

International disparities in use of antenatal magnesium sulfate and antenatal steroids for the preterm baby

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Antenatal magnesium sulfate (MgSO4) and antenatal steroids (ANS) are evidence‐based interventions that reduce risk of cerebral palsy and respiratory complications in preterm babies. They are recommended in clinical guidelines internationally. However, we have limited information on how well they are being implemented.
Hannah B. Edwards   +14 more
wiley   +1 more source

Balloon catheter plus concurrent vaginal misoprostol versus vaginal misoprostol alone for cervical ripening in induction of labor: A systematic review and an individual participant data meta‐analysis of randomized controlled trials

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Cervical ripening in labor induction using a combination of methods is gaining popularity, but the effectiveness and safety of this approach are not clear. The assessment of study trustworthiness has recently been raised for evidence synthesis.
Malitha Patabendige   +13 more
wiley   +1 more source

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