Results 81 to 90 of about 181,054 (296)

Mechanisms of SCN2A loss of function do not predict presence or phenotype of epilepsy

Epilepsia, EarlyView.
Abstract Objective SCN2A loss‐of‐function (LoF) variants are associated with epilepsy (onset age ≥ 3 months), intellectual disability (ID), and autism spectrum disorder (ASD). Despite numerous identified variants and the description of phenotypic subgroups, relationships between Nav1.2 channel dysfunction and clinical phenotypes remain unclear.
Marsha Tan, Beatrice Southby Goad, Meagan Allen, Jill Rodda, Kay L. Richards, Simone L. Ardern‐Holmes, Daniel Bamborschke, Daniel Fritzen, Inna Hughes, Kate Riney, Ana Roche Martinez, Angelo Russo, Adriane Sinclair, Stefano Sartori, Marina Trivisano, Angela De Dominicis, Nicola Specchio, Rikke S. Møller, Ingrid E. Scheffer, Walid Fazeli, Markus Wolff, Steven Petrou, Katherine B. Howell, Géza Berecki   +23 more
wiley   +1 more source

Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults [PDF]

, 2015
Background Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are worldwide treatment options for multinodular non-toxic goitre in adults.
Arezzo, Alberto, Avenia, Nicola, Barczyñski, Marcin, Cirocchi, Roberto, D'Andrea, Vito, DI ROCCO, Giorgio, Guarino, Salvatore, Randolph, Justus, Santoro, Alberto, Trastulli, Stefano   +9 more
core   +2 more sources

Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug‐resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social–emotional skill development are limited.
Ingrid E. Scheffer, M. Scott Perry, Joseph Sullivan, Susana Boronat, James Wheless, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +26 more
wiley   +1 more source

Validation of the Registered Nurse Assessment of Readiness for Hospital Discharge Scale [PDF]

, 2018
Background Statistical models for predicting readmissions have been published for high-risk patient populations but typically focus on patient characteristics; nurse judgment is rarely considered in a formalized way to supplement prediction models ...
Bobay, Kathleen L., Oswald, Debra L., Weiss, Marianne E., Yakusheva, Olga   +3 more
core   +3 more sources

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

A rewriting of Pygmalion from a female (and feminist) perspective: «Galatea» by Madeline Miller.

Griseldaonline
In the context of contemporary publishing, which has witnessed the considerable success of the genre of female mythological retelling, Madeline Miller is a notable figure.
Chiara Valenzano
doaj   +1 more source

Publij Ovidij Nazon: Metamorfoze 10–12

Keria: Studia Latina et Graeca, 2018
Skozi neznanski se eter v žafranastem plašču odpravil potlej Himén je; urezal je pot v deželo Kikoncev, kamor ga Orfejev glas zaman je vabil in klical.
Joža Lovrenčič
doaj   +1 more source

Association Between Non-Cigarette/Smokeless Tobacco and Hypertension in the National Health Interview Survey: a Pseudo-Panel Analysis [PDF]

, 2016
This study sought to examine assumption between having ever used non-cigarette tobacco or smokeless tobacco, and a diagnosis of hypertension among a sample of 13, 086 United States adults participating in the National Health Interview Series from 2012 ...
Akinola, O. (Olubusayo), Commodore-Mensah, Y. (Yvonne), Obisesan, A. (Adekunle), Obisesan, O. (Olawunmi), Thompson, E. (Emmanuel)   +4 more
core  

The 2016 HIGh Heels: Health effects and psychosexual benefITS (HIGH HABITS) study : systematic review of reviews and additional primary studies [PDF]

, 2017
Acknowledgements We thank S.M. Barran (Guy’s and St Thomas NHS Foundation Trust) for general comments on the topic and its social context. We thank S. Reynolds for comments as a member of the public on the introduction and discussion, in particular with ...
Barnish, Jean, Barnish, Max, Morgan, Heather May   +2 more
core   +4 more sources

Defining the end point of status epilepticus: A scoping review and framework for standardization

Epilepsia, EarlyView.
Abstract Status epilepticus (SE) is a life‐threatening neurological emergency with consensus‐driven definitions for onset but no standardized criteria for its end point. This gap creates uncertainty in research and clinical practice. We conducted a scoping review to evaluate how end points have been defined in SE research and to identify key areas of ...
Fawad A. Khan, Margaret T. Gopaul, Samuel L. Carter, Anil Chimakurthy, Summer Skelton, Lawrence J. Hirsch, Eugen Trinka   +6 more
wiley   +1 more source