Results 61 to 70 of about 181,054 (296)

Clinical Development of Targeted Fragile X Syndrome Treatments: An Industry Perspective

open access: yesBrain Sciences, 2018
Fragile X syndrome (FXS) is the leading known cause of inherited intellectual disability and autism spectrum disorder. It is caused by a mutation of the fragile X mental retardation 1 (FMR1) gene, resulting in a deficit of fragile X mental retardation ...
Anna W. Lee   +4 more
doaj   +1 more source

Effects of community participation on improving uptake of skilled care for maternal and newborn health: a systematic review. [PDF]

open access: yes, 2013
BACKGROUND: Despite a broad consensus that communities should be actively involved in improving their own health, evidence for the effect of community participation on specific health outcomes is limited.
Marston, Cicely   +3 more
core   +3 more sources

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo   +8 more
wiley   +1 more source

Mit cyklopa w antyku i literaturze hiszpańskiej złotych wieków [PDF]

open access: yes, 2014
W literaturze starożytnej obecne są dwa, biegunowo odmienne, motywy podania o Cyklopie: epicki, znany z IX ks. Odysei, przywołany później i poddany modyfikacji przez Eurypidesa w dramacie satyrowym Cyklop oraz liryczno-erotyczny spopularyzowany ...
Kłosińska-Nachin, Agnieszka   +1 more
core  

Effective communication in eliciting and responding to suicidal thoughts: a systematic review protocol [PDF]

open access: yes, 2016
Background In the UK, over 6500 people die by suicide each year. In England alone, this is one person every 2 h. Professionals assess risk of suicide in face-to-face contacts with people potentially at risk.
Backhouse, A.   +3 more
core   +1 more source

Content Validation of a Medication Adherence Risk Score (MARS) for Mortality Risk Prediction: A Delphi Consensus

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The Medication Adherence Risk Score (MARS) is an objective adherence‐based score, derived from transactional dispensary data. This study provides expert consensus to validate the use of the MARS as a predictor of mortality risk. A systematic review and assessment of South African health legislation and professional guidelines informed the development ...
Jessica Hamuy Blanco   +3 more
wiley   +1 more source

Antisense oligonucleotides to KIF1A polymorphisms expand targets and rescue patient-derived neurons in vitro

open access: yesNature Communications
Dominant negative pathogenic variants in KIF1A result in an allelically heterogeneous neurodegenerative condition that manifests as a variable clinical phenotype including seizures, cognitive deficits, optic nerve atrophy, spasticity, and peripheral ...
Michael V. Zuccaro   +13 more
doaj   +1 more source

An isoperibol calorimeter for the investigation of biochemical kinetics and isothermal titration calorimetry [PDF]

open access: yes, 2007
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes bibliographical references (leaf 52).Isothermal titration calorimetry is a technique used to measure the enthalpy change associated with a molecular ...
Amadi, Ovid Charles
core  

Financial Toxicity Associated with Biological Medicines: A Scoping Review

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka   +4 more
wiley   +1 more source

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