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A Vaccine Targeting Ovine Herpesvirus 2 Glycoprotein B Protects against Sheep-Associated Malignant Catarrhal Fever [PDF]

Vaccines, 2022
Malignant catarrhal fever (MCF) is a complex and often fatal disease of ungulates. Effective vaccines are needed to avoid MCF outbreaks and mitigate losses.
Cristina W. Cunha, Katherine N. Baker, Donal O’Toole, Emily Cole, Smriti Shringi, Benjamin G. Dewals, Alain Vanderplasschen, Hong Li   +7 more
doaj   +2 more sources

First Molecular Evidence and Genetic Characterization of Ovine Herpesvirus 2 in Multiple Animal Species in India [PDF]

Frontiers in Veterinary Science, 2021
Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a highly fatal disease syndrome that predominantly affects susceptible hosts of the order Artiodactyla.
Naveen Kumar, Richa Sood, Atul K. Pateriya, E. Venkatesakumar, R. Ramprabhu, Roma Dixit, Sandeep Bhatia, Vijendra Pal Singh   +7 more
doaj   +2 more sources

Ovine Herpesvirus 2 Glycoprotein B Complementation Restores Infectivity to a Bovine Herpesvirus 4 gB-Null Mutant [PDF]

Pathogens
Ovine herpesvirus 2 (OvHV-2) and bovine herpesvirus 4 (BoHV-4) are gamma herpesviruses that belong to the genera Macavirus and Rhadinovirus, respectively.
Daniela D. Moré, Katherine N. Baker, Smriti Shringi, Reginaldo G. Bastos, Donal O’Toole, Gaetano Donofrio, Cristina W. Cunha   +6 more
doaj   +2 more sources

The Cytoplasmic Tail of Ovine Herpesvirus 2 Glycoprotein B Affects Cell Surface Expression and Is Required for Membrane Fusion [PDF]

Viruses
Ovine herpesvirus 2 (OvHV-2) causes the fatal veterinary disease malignant catarrhal fever (MCF). Fusion is an essential step in the host cell entry of enveloped viruses and is an important target for vaccine development.
Colleen M. Lynch, Maria K. Herndon, McKenna A. Hull, Daniela D. Moré, Katherine N. Baker, Cristina W. Cunha, Anthony V. Nicola   +6 more
doaj   +2 more sources

Replacement of Glycoprotein B in Alcelaphine Herpesvirus 1 by Its Ovine Herpesvirus 2 Homolog : Implications in Vaccine Development for Sheep-Associated Malignant Catarrhal Fever [PDF]

mSphere, 2016
Vaccine development is a top priority in malignant catarrhal fever (MCF) research. In the case of sheep-associated MCF (SA-MCF) caused by ovine herpesvirus 2 (OvHV-2), progress toward this objective has been hindered by the absence of methods to ...
Cristina W. Cunha, Naomi S. Taus, Benjamin G. Dewals, Alain Vanderplasschen, Donald P. Knowles, Hong Li   +5 more
doaj   +2 more sources

Expression of ovine herpesvirus -2 encoded microRNAs in an immortalised bovine - cell line. [PDF]

PLoS ONE, 2014
Ovine herpesvirus-2 (OvHV-2) infects most sheep, where it establishes an asymptomatic, latent infection. Infection of susceptible hosts e.g. cattle and deer results in malignant catarrhal fever, a fatal lymphoproliferative disease characterised by ...
Katie Nightingale, Claire S Levy, John Hopkins, Finn Grey, Suzanne Esper, Robert G Dalziel   +5 more
doaj   +2 more sources

Molecular Analysis of South African Ovine Herpesvirus 2 Strains Based on Selected Glycoprotein and Tegument Genes. [PDF]

PLoS ONE, 2016
Ovine herpesvirus 2 (OvHV-2), is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a generally fatal disease of cattle and other captive wild ruminants.
Fulufhelo Amanda Doboro, Stephen Njiro, Kgomotso Sibeko-Matjila, Moritz Van Vuuren   +3 more
doaj   +2 more sources

Viral contamination in cell culture: analyzing the impact of Epstein Barr virus and Ovine Herpesvirus 2 [PDF]

Frontiers in Microbiology
Cell culture techniques are increasingly favored over animal models due to rising costs, time constraints, and ethical concerns regarding animal use. These techniques serve critical roles in disease modeling, drug screening, drug discovery, and toxicity ...
Iman M. Bastawecy, Mohamed Abdelmonem, Ahmed F. Afify, Norazalina Saad, Yuki Shirosaki, Yuki Shirosaki, Yuki Shirosaki, Che Azurahanim Che Abdullah, Rania F. El Naggar, Mohammed A. Rohaim, Mohammed A. Rohaim, Muhammad Munir   +11 more
doaj   +2 more sources

Molecular prevalence and risk factors of ovine herpesvirus-2–associated malignant catarrhal fever in cattle from Riau Province, Indonesia: A cross-sectional nested polymerase chain reaction study [PDF]

Veterinary World
Background and Aim: Malignant catarrhal fever (MCF) is a highly fatal disease caused by ovine herpesvirus-2 (OvHV-2), with sheep acting as asymptomatic reservoir hosts.
Annisa Yohanes, Dyah Ayu Widiasih, Agus Wiyono, Rini Damayanti, Faralinda Sari, Dewi Anggreini   +5 more
doaj   +2 more sources

Two Different Macaviruses, ovine herpesvirus-2 and caprine herpesvirus-2, behave differently in water buffaloes than in cattle or in their respective reservoir species. [PDF]

PLoS ONE, 2013
The ongoing global spread of "exotic" farm animals, such as water buffaloes, which carry their native sets of viruses, may bear unknown risks for the animals, into whose ecological niches the former are introduced and vice versa.
Anina B J Stahel, Rhea Baggenstos, Monika Engels, Martina Friess, Mathias Ackermann   +4 more
doaj   +2 more sources