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Veterinary Pathology, 2020
Cross-species infection with ovine herpesvirus 2 (OvHV-2) in cattle causes malignant catarrhal fever (MCF). MCF may involve the central nervous system (CNS) with necrotizing arteritis and/or vasculitis described to be unique to MCF and discriminatory compared to other viral CNS infections. However, a systematic histopathological characterization of the
Melanie M. Hierweger +5 more
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Cross-species infection with ovine herpesvirus 2 (OvHV-2) in cattle causes malignant catarrhal fever (MCF). MCF may involve the central nervous system (CNS) with necrotizing arteritis and/or vasculitis described to be unique to MCF and discriminatory compared to other viral CNS infections. However, a systematic histopathological characterization of the
Melanie M. Hierweger +5 more
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Quantification of ovine herpesvirus 2 by digital PCR in an outbreak of malignant catarrhal fever
Archives of Virology, 2019Infection with ovine gammaherpesvirus 2 (OvHV-2) is generally asymptomatic in sheep; however, when it crosses the species barrier, it causes malignant catarrhal fever (MCF) in cattle. In the present study, we developed a real-time PCR assay and a droplet digital PCR assay and use both methods to study an outbreak caused by OvHV-2.
Tatiana Flávia Pinheiro de Oliveira +13 more
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Malignant catarrhal fever in cows due to ovine herpesvirus type 2
Veterinary Record, 2011Outbreak of malignant catarrhal fever in cows Review of coccidiosis in calves in 2010 Unusually high incidence of
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Identification of peripheral blood mononuclear cells targeted by Ovine herpesvirus-2 in sheep
Veterinary Microbiology, 2010Sheep-associated malignant catarrhal fever (MCF), caused by Ovine herpesvirus 2 (OvHV-2), is usually a fatal disease of various ruminants and swine. In contrast, natural OvHV-2 infection in sheep, which are the main OvHV-2 reservoir, proceeds without any clinical symptoms.
Meier-Trummer, C S, Ryf, B, Ackermann, M
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The molecular pathogenesis of Ovine Herpesvirus 2
2018Malignant catarrhal fever (MCF) is a lymphoproliferative and inflammatory disease of cattle, deer and other ruminants. It is caused mainly by one of two herpesviruses, alcelaphine herpesvirus 1 (A1HV-1) and ovine herpesvirus 2 (OvHV-2). A1HV-1 can be grown in tissue culture; its complete genome has been sequenced and the virus characterised as a ...
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Validation and functional analysis of Ovine Herpesvirus 2-encoded microRNAs
2017Ovine herpesvirus 2 (OvHV-2) is a gammaherpesvirus of domestic sheep and causes the lymphoproliferative disease malignant catarrhal fever (MCF) in susceptible ruminants, including cattle. Sheep are latently infected but do not develop disease. MCF is characterised by proliferation of non-antigen specific cytotoxic large granular lymphocytes which leads
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Identification and characterization of Ovine Herpesvirus 2 microRNAs
2012Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever (MCF) in susceptible ruminants. Through an unknown mechanism, presence of the virus leads to proliferation of NK-like T cells that are not targetrestricted by the MHC class molecules.
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Development of a Diagnostic-Serological Assay for Ovine Herpesvirus-2
2018ction of antibodies against MCFV. Potentially antigenic components of the ELISA lysate were analysed by western blotting in comparison with other bovine herpesviruses, and fractionation by gel filtration showed clear antigenic bands in the eluent. Proteomic analysis of antigenic bands identified proteins encoding viral thymidine kinase (ORF21), a virus
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Functional analysis of ovine herpesvirus 2 encoded microRNAs
2015Ovine herpesvirus 2 (OvHV-2) is a gamma herpesvirus and is the causative agent of lymphoproliferative disease – sheep-associated malignant catarrhal fever in susceptible ruminants, including cattle. Sheep become persistently infected but do not show apparent clinical infection.
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