Results 131 to 140 of about 850,210 (308)

Successful ability to stay at home - an interview study exploring multiple diagnosed older persons and their relatives’ experiences

BMC Geriatrics
Background Society places increased demands on regions and municipalities to jointly carry out activities for multi-diagnosed older persons with extensive coordination needs.
Lena-Karin Gustafsson, Anna Bondesson, Tina Pettersson, Gunnel Östlund   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Usability and Image Resource Interfaces: five steps to plan your own study

, 2020
Usability testing, a systematic approach to finding out what parts of a tool or resource are difficult to use, can be particularly useful with digital image systems and other visual resources.
Clark, Melanie
core  

Mineral resources base of Ukraine. Article 4. Fuel and energy resources and perspectives of their capacity

Мінеральні ресурси України, 2015
In the article characterized the current state fuel and energy resources and perspectives of their capacity in accordance with the State Program on the development of mineral resources base of Ukraine for the period until 2030.
M. D. Krasnozhon
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Family Resources Survey, 2005/06-2023/24: Secure Access

copyright UK Data Service and data collection copyright owner.The Family Resources Survey (FRS) has been running continuously since 1992 to meet the information needs of the Department for Work and Pensions (DWP).
Department for Work and Pensions, Office for National Statistics, Social and Vital Statistics Division, NatCen Social Research   +2 more
core  

Litigant Resources and the Evolution of Legal Precedent [PDF]

This paper develops an informational model of litigation in which court decisions are a function of legal representation. In this model, resource constraints determine how much parties expend on legal representation.
Richard Startz, Albert Yoon
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Geographical Referencing resources for social scientists (Geo-Refer)

, 2008
A set of modular online learning resources covering geographical data linkage and mapping, mainly focused on the UK and dealing with census, postcode and administrative geographies, deprivation indicators and other major geographically-referenced ...
Martin, David, Leung, Samuel, Cockings, Samantha   +2 more
core  

STRUCTURIZATION OF OWN FUEL-ENERGY RECOURSES OF THE REPUBLIC OF BELARUS IN BASIC DIRECTIONS OF CONSUMPTION

Наука и техника, 2008
On the basis of an analysis of scientific, reference and encyclopaedic literature, statistical information, and also main documents concerning power engineering policy a composition systemization of «own fuel-energy recourses» and «local fuel-energy ...
Y. N. Rumiantsava
doaj