Results 101 to 110 of about 6,948,837 (250)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Evaluation Criteria of the EU’s Own Resources
Gdańskie Studia PrawniczeThe author in this article examines the assessment criteria of the EU’s own resources budget. The main goal of this article is to establish an up-to-date, effective system of evaluation criteria for the EU’s own resources budget. To achieve this, the article assesses the evaluation criteria for the EU’s own resources budget through the objectives of ...
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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State-federal relationships in water resources development programs. [1956 - Bulletin 2]
, 1956 "Federal participation in the development of water resources projects and programs in the State of Kansas can be expected to approach a billion dollars... The over-all impact of these federal programs is tremendous.
Kansas. State Water Resources Board.
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Herland Sister Resources : v.1: no.2(1985) [PDF]
, 1985 The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
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Herland Sister Resources : v.5: no.9(1988) [PDF]
, 1985 The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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A rational system of the own resources for the European Community
Economics and Business Review, 2005 A system of EC own resources needs a comprehensive reform because it does not correspond with the new reality of enlarged European Union (EU). The system analysis according to the own resources criteria in federal country proves that the present system of EC resources neither guarantees EC financial autonomy nor equity in taxation between Member States
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