Results 61 to 70 of about 850,210 (308)

MODERN TYPES OF FINANCING LARGE INVESTMENT PROJECTS (NUCLEAR POWER PLANT CONSTRUCTION)

open access: yesСтратегические решения и риск-менеджмент, 2015
Large investment projects require raising high volumes of financial resources on the long term. There is a task now set to raise private capital into the power field more actively and to develop state-private partnership.
А. M. Kryukov, L. T. Yanko, V. V. Kuhto
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fiscal austerity and municipal health spending: an interrupted time series study [PDF]

open access: yesRevista de Saúde Pública
OBJECTIVE To analyze the impact of the fiscal austerity policy (PAF) on health spending in Brazilian municipalities, considering population size and source of funds.
Leo Ramos Maia   +2 more
doaj   +1 more source

Fully connecting the Observational Health Data Science and Informatics (OHDSI) initiative with the world of linked open data [PDF]

open access: yesGenomics & Informatics, 2019
The usage of controlled biomedical vocabularies is the cornerstone that enables seamless interoperability when using a common data model across multiple data sites.
Juan M. Banda
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Tax-based EU own resources: an assessment [PDF]

open access: yes
The ongoing intergovernmental conference (IGC) and the preparation of the "Financial Perspectives post-2006" i.e. the next multi-annual financial framework of the European Union, have led to new discussions on the issue of EU own taxes.
Philippe Cattoir
core  

In sickness and in health: The role of marital partners in cancer survival

open access: yesSSM: Population Health, 2017
Married cancer patients enjoy a survival advantage, potentially attributable to better health at diagnosis, earlier contact with health personnel, and/or access to resources to ensure more optimal treatment. These mechanisms only invoke the mere presence
Astri Syse, Torkild Hovde Lyngstad
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The EU Budget: The UK Rebate and the CAP – Phasing them both out? CEPS Task Force Reports, 8 November 2007 [PDF]

open access: yes, 2007
In a groundbreaking speech in the European Parliament in June 2005, the then British Prime Minister Tony Blair effectively signalled room for negotiation on the UK rebate in exchange for fundamental reform of the EU budget, with particular reference to ...
Nunez Ferrer, Jorge.
core  

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