Results 91 to 100 of about 40,783 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Ownership concentration, market monitoring and performance: Evidence from the UK, the Czech Republic and Poland [PDF]

open access: yes
Using data for publicly traded companies from the UK and two transition countries, the Czech Republic and Poland, we analyze the relationship between ownership concentratio and performance while also accounting for the effect of hostile takeover threats ...
Mariana Spatareanu, Vahe Lskavyan
core  

Konsentrasi Kepernilikan Media dan Ancaman Ruang Publik

open access: yesJSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2008
The trend toward the concentration of media ownership in the hand of few media moguls in many parts of the world has been a subject of criticism. Concentration of media ownership has been one of the main threat to democracy and public sphere.
- Eriyanto
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

The Evolution of Ownership Structure in Firms Privatized through Wholesale Schemes in the Czech Republic and Poland [PDF]

open access: yes
We compare the change in ownership concentration in firms privatized through two different programs of mass privatization: the Czech voucher scheme and the Polish program of National Investment Funds.
Irena Grosfeld, Iraj Hashi
core  

The effect of the ownership concentration on earnings management. Empirical evidence from the Italian context [PDF]

open access: yes, 2017
The numerous cases of business disruptions, involving opportunism and accounting fraud by shareholder, directors and managers, that have occurred in different countries over the past two decades along with institutional and context phenomena and with the
GRIMALDI, F.   +3 more
core   +1 more source

Ownership Concentration and Share Valuation: Evidence from Germany [PDF]

open access: yes
Concentrated ownership of large listed companies is widespread throughout the world, and Germany is typical in this respect. This paper proposes a method of distinguishing empirically between the beneficial and harmful effects of ownership concentration,
Jeremy Edwards, Alfons Weichenrieder
core   +2 more sources

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