Results 281 to 290 of about 47,533 (300)

Altered glutathione metabolism in oxaliplatin resistant ovarian carcinoma cells

Cancer Letters, 1996
Elevation of glutathione (GSH) is commonly observed in cellular resistance to a number of anticancer agents. Most frequently reported change in GSH metabolism that is associated with the elevated GSH levels is increased mRNA expression and activity of gamma-glutamyl cysteine synthetase (gamma GCS), the first enzyme of the GSH biosynthetic pathway.
Z, el-akawi, M, Abu-hadid, R, Perez, J, Glavy, J, Zdanowicz, P J, Creaven, L, Pendyala   +6 more
openaire   +2 more sources

Cellular Resistance to Oxaliplatin and Drug Accumulation Defects

2009
Platinum drugs are employed in a wide range of solid tumors, and represent the mainstay of the first-line therapy of ovarian carcinoma. Although cisplatin has shown efficacy in the treatment of different types of tumors including ovarian carcinoma, resistance to treatment is a major limitation.
Laura Gatti, Paola Perego
openaire   +1 more source

TGFB1-mediated autophagy facilitates oxaliplatin resistance in stomach adenocarcinoma

Biochemistry and Cell Biology
Increasing evidence has indicated that transforming growth factor beta 1 (TGFB1) is engaged in tumorigenesis and progression. Nevertheless, the underlying role and mechanism of TGFB1 in stomach adenocarcinoma (STAD) chemotherapy remains unknown. TGFB1 levels in various types of cancers were first analyzed by the TCGA database.
Qihua Xu, Sheng Hu, Qilin Zhang, Huijun Zhang, Jianfeng Liu, Ying Zhou, Tianning Tian, Bingling Liao   +7 more
openaire   +2 more sources

Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer

Molecular Therapy, 2021
Haiyang Zhang, Xinyi Wang, Kegan Zhu
exaly  

Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer

Bioorganic Chemistry, 2021
Yujun Cui, Shengnan Liu, Qingzhi Gao
exaly  

Oxaliplatin and its derivatives – An overview

Coordination Chemistry Reviews, 2023
Paul D O'Dowd, Darragh F Sutcliffe, Darren M Griffith   +2 more
exaly  

NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling

Cancer Letters, 2018
Zejun Fang, Chaoju Gong, Waseem Hassan   +2 more
exaly  

Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells

Cancers, 2019
Soyeon Jeong, Bu Gyeom Kim, Sun Il Lee
exaly  

The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells

Biomedicine and Pharmacotherapy, 2018
Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Mohammad Reza Sadeghi   +2 more
exaly  

Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells

Cancer Chemotherapy and Pharmacology, 2005
Mary W Davey, Ross A Davey
exaly