Results 91 to 100 of about 7,735 (257)

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.

open access: yesGastroenterology, 2016
BACKGROUND & AIMS Many colorectal cancer (CRC) cells contain mutations in KRAS. Analyses of CRC cells with mutations in APC or CTNNB1 and KRAS identified SLC25A22, which encodes mitochondrial glutamate transporter, as a synthetic lethal gene.
C. Wong   +16 more
semanticscholar   +1 more source

Pyruvic and oxaloacetic cyanohydrins [PDF]

open access: yesBiochemical Journal, 1937
Stanley William Williamson   +1 more
openaire   +3 more sources

The multifaceted roles of ketones in physiology

open access: yesExperimental Physiology, EarlyView.
Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili   +3 more
wiley   +1 more source

A novel hydantoin synthesis and exploration of related reactions [PDF]

open access: yes
Chapter one gives a short history of the discovery of hydantoins, followed by their chemical properties and reactivity and concluding with the many ways to date that they have been synthesized.
Leonard, M
core  

Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants.

open access: yesMolecular plant pathology, 2015
The oxaloacetate acetylhydrolase (OAH, EC 3.7.1.1)-encoding gene Ss-oah1 was cloned and functionally characterized from Sclerotinia sclerotiorum. Ss-oah1 transcript accumulation mirrored oxalic acid (OA) accumulation with neutral pH induction dependent ...
Xiaofei Liang   +6 more
semanticscholar   +1 more source

A simulation study on the role of mitochondria‐sarcoplasmic reticulum Ca2+ interaction in cardiomyocyte energetics during exercise

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend An integrated model of human ventricular myocyte with excitation‐contraction‐energetics coupling was created to systematically analyse the contribution of Ca2+ regulation of mitochondrial enzymes to cardiomyocyte functions during workload transition; i.e. exercise.
Ayako Takeuchi, Satoshi Matsuoka
wiley   +1 more source

The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

open access: yesAnimals, 2015
The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in ...
H. White
semanticscholar   +1 more source

Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Two weeks of bed rest lowers skeletal muscle mass and strength. Daily passive blood flow restriction during bed rest does not modulate daily muscle protein synthesis and does not preserve skeletal muscle mass or strength. Created with BioRender.com.
Cas J. Fuchs   +10 more
wiley   +1 more source

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