Results 131 to 140 of about 7,735 (257)

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Proceedings of the National Academy of Sciences of the United States of America, 2007
R. Deberardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, C. Thompson   +6 more
semanticscholar   +1 more source

Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
Neurodevelopment is orchestrated by precise metabolic regulation. Key metabolic processes—glucose, lipid, and amino acid metabolism—drive cell proliferation, differentiation, synaptogenesis, and neurotransmitter synthesis. These are tightly integrated with signaling pathways like mTOR, AMPK, and insulin/IGF that regulate neuronal growth and synaptic ...
Yanqing He, Kang Xie, Kang Yang, Nianhua Wang, Longbo Zhang   +4 more
wiley   +1 more source

Combined systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) predicts chemotherapy response and prognosis in locally advanced gastric cancer patients receiving neoadjuvant chemotherapy with PD-1 antibody sintilimab and XELOX: a prospective study. [PDF]

BMC Gastroenterol, 2022
Ding P, Guo H, Sun C, Yang P, Kim NH, Tian Y, Liu Y, Liu P, Li Y, Zhao Q.   +9 more
europepmc   +1 more source

Some Lactobacillus l -Lactate Dehydrogenases Exhibit Comparable Catalytic Activities for Pyruvate and Oxaloacetate [PDF]

, 2001
Kazuhito Arai, Takeo Kamata, H. Uchikoba, Shinya Fushinobu, Hiroshi Matsuzawa, Hayao Taguchi   +5 more
openalex   +1 more source

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production, highlighting the critical role these enzymes play in cellular energy metabolism.
László Juhász, Krisztina Spisák, Boglárka Zsuzsa Szolnoki, Anna Nászai, Ágnes Szabó, Attila Rutai, Szabolcs Péter Tallósy, Andrea Szabó, József Toldi, Masaru Tanaka, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, Etsuro Ono, Mihály Boros, József Kaszaki, László Vécsei   +17 more
wiley   +1 more source

Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells. [PDF]

PLoS One, 2022
Hatipoglu A, Menon D, Levy T, Frias MA, Foster DA.   +4 more
europepmc   +1 more source

Bacillus subtilisYisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization [PDF]

, 2023
Tingfeng Guo, Anthony M. Sperber, Inna V. Krieger, Yi Duan, Veronica R. Chemelewski, James C. Sacchettini, Jennifer K. Herman   +6 more
openalex   +1 more source

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Proceedings of the National Academy of Sciences of the United States of America, 2011
David R. Wise, P. Ward, Jessica E. S. Shay, J. Cross, J. Gruber, Uma M. Sachdeva, Jesse M. Platt, Raymond G Dematteo, M. Simon, C. Thompson   +9 more
semanticscholar   +1 more source

A randomized phase II trial comparing capecitabine with oxaliplatin or docetaxel as first-line treatment in advanced gastric and gastroesophageal adenocarcinomas. [PDF]

Medicine (Baltimore), 2021
Ni L, Zhang W, Chen Y, Leng W, Gou H, Hu J, Qiu M.   +6 more
europepmc   +1 more source

Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel l-lactate translocators [PDF]

, 2004
Lidia de Bari, Anna Atlante, Daniela Valenti, Salvatore Passarella   +3 more
openalex   +1 more source