Results 11 to 20 of about 69 (69)

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice

Aging Cell, Volume 24, Issue 4, April 2025.
Tert knock‐in (TertKI) mice harboring the EF1α‐Tert gene in the Rosa26 locus displayed heightened telomerase activity, elongated telomeres, and extended lifespan. TertKI mice displayed enhanced wound healing and exhibited resistance to the progression of colitis.
Tian‐Yi Zhu, Po Hu, Yu‐Hui Mi, Jun‐Li Zhang, An‐Na Xu, Ming‐Tong Gao, Ying‐Ying Zhang, San‐Bing Shen, Guang‐Ming Yang, Yang Pan   +9 more
wiley   +1 more source

Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation

Biological Reviews, EarlyView.
ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison, Josiane Hérault, Justine Marchand, Lionel Ulmann   +3 more
wiley   +1 more source

Skeletal muscle mitochondrial correlates of critical power and W' in healthy active individuals

Experimental Physiology, EarlyView.
Abstract The asymptote (critical power; CP) and curvature constant (W') of the hyperbolic power–duration relationship can predict performance within the severe‐intensity exercise domain. However, the extent to which these parameters relate to skeletal muscle mitochondrial content and respiratory function is not known.
Donald L. Peden, Robert Rogers, Emma A. Mitchell, Suzanne M. Taylor, Stephen J. Bailey, Richard A. Ferguson   +5 more
wiley   +1 more source

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications

The Journal of Physiology, EarlyView.
Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh, Ming Chuen Chong, Alexander D. Miras, Carel W. le Roux   +3 more
wiley   +1 more source

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

The role of heat shock proteins in placental ischemic disease: A narrative review of the current literature

International Journal of Gynecology &Obstetrics, Volume 169, Issue 3, Page 960-967, June 2025.
Abstract Pre‐eclampsia, placental abruption, and fetal growth restriction (FGR) are collectively referred to as placental ischemic disease (PID). Heat shock proteins (HSPs), originally considered as a response to the heat shock, have a central role in regulating the cellular functions by quality controlling the newly synthesized proteins.
Athina A. Samara, Anastasios Lafioniatis, Maria Ioannou, Sofia Tsiapakidou, Angeliki Gerede, Eleftherios Anastasakis, Alexandros Daponte, Sotirios Sotiriou   +7 more
wiley   +1 more source

Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II–driven respiration [PDF]

Journal of Biological Chemistry, 2018
We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant ("clamped") at sequentially increasing concentrations in succinate-energized muscle mitochondria in the absence of rotenone (commonly used to block complex I), we observed a biphasic, increasing then decreasing, respiratory response.
Eric B. Taylor, Brian D. Fink, William I. Sivitz, Fan Bai, Liping Yu, Arpit Sharma, Ryan D. Sheldon   +6 more
openaire   +3 more sources

Targeting KRAS Sensitizes Ferroptosis by Coordinately Regulating the TCA Cycle and Nrf2‐SLC7A11‐GPX4 Signaling in Hepatocellular Carcinoma

Smart Medicine, Volume 4, Issue 2, June 2025.
Molecular target engagements and metabolic changes reveal that NSC48160 inhibits the progression of HCC through ferroptosis. NSC48160 elucidates the ferroptosis mechanism whereby it impedes KRAS and instigates the downregulation of Nrf2/SLC7A11/GPX4.
Jiaxin Zhang, Zuojia Liu, Wenjing Zhao, Chang Li, Fei Liu, Jin Wang   +5 more
wiley   +1 more source