Results 11 to 20 of about 2,492 (186)

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Switchable Coumarins for Ratiometric pH Sensing

Frontiers in Materials, 2021
A fluorescent chromophore and a pH-sensitive heterocycle were integrated within a single covalent skeleton to generate four molecular switches with ratiometric fluorescence response.
Mercedes M. A. Mazza, Francesca Cardano, Francesca Cardano, Francesca Cardano, James D. Baker, Silvia Giordani, Silvia Giordani, Françisco M. Raymo   +7 more
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Use of Phenyl Formate as a CO Surrogate for the Reductive Cyclization of Organic Nitro Compounds to Yield Different N-Heterocycles: Avoiding the Use of Autoclaves and Pressurized Gases

Chemistry Proceedings, 2022
The reductive cyclization of different organic nitro compounds by carbon monoxide, catalyzed by transition metal complexes, is a very efficient and clean strategy for the synthesis of many N-heterocycles.
Fabio Ragaini, Francesco Ferretti, Manar Ahmed Fouad   +2 more
doaj   +1 more source

Oxazinethione Derivatives as a Precursor to Pyrazolone and Pyrimidine Derivatives: Synthesis, Biological Activities, Molecular Modeling, ADME, and Molecular Dynamics Studies

Molecules, 2021
In this study, we used oxazinethione as a perfect precursor to synthesize new pyrimidine and pyrazole derivatives with potent biological activities. Biological activities were determined for all compounds against A. flavus, E. coli, S.
Magda H. Abdellattif, Mohd Shahbaaz, M. M. H. Arief, Mostafa A. Hussien   +3 more
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Cycloaddition of 4-Acyl-1H-pyrrole-2,3-diones Fused at [e]-Side and Cyanamides: Divergent Approach to 4H-1,3-Oxazines

Molecules, 2022
4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles.
Ekaterina E. Khramtsova, Aleksandr D. Krainov, Maksim V. Dmitriev, Andrey N. Maslivets   +3 more
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Synthesis, crystal structure and Hirshfeld surface analysis of 1,7-dimethyl-5a,6,11a,12-tetrahydrobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine

Acta Crystallographica Section E: Crystallographic Communications, 2020
Molecules of the title compound, C16H16N2O2, occupy special positions on the twofold rotation axes. The heterocyclic ring adopts a slightly twisted envelope conformation with one of the two junction carbon atoms as the flap.
Emine Berrin Çınar, Semanur Yeşilbağ, Onur Erman Doğan, Erbil Ağar, Necmi Dege, Eiad Saif   +5 more
doaj   +1 more source

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. [PDF]

PLoS ONE, 2016
Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases.
Anilkumar C Nirvanappa, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Hanumappa Ananda, Alexey Yu Sukhorukov, Muthu K Shanmugam, Mahalingam S Sundaram, Siddaiah Chandra Nayaka, Kesturu S Girish, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Basappa, Kanchugarakoppal S Rangappa   +14 more
doaj   +1 more source

SUBSTITUTED 4-NITROSOPYRAZOLES IN THE DIELS-ALDER REACTION

Siberian Journal of Life Sciences and Agriculture, 2021
Background. 4-Nitrosopyrazoles have become widespread in the pharmaceutical industry and in chemistry due to their high reactivity and biological activity. However, the interaction of 3,5-substituted 4-nitroso-1H-pyrazoles with diene hydrocarbons has not
Darya S. Volkova, Arkadiy A. Popov, Evgeny V. Root, Alexey A. Kukushkin, George A. Suboch   +4 more
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Interaction of 3H-furan-2-ones and 4-oxobutanoic acids with 2-(aminophenyl)methanol [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2022
Reactions of 4-oxobutanoic acids as well as their cyclic analogues 3H-furan-2-ones with 1,3-binucleophilic reagent (2-aminophenyl) methanol lead to the formation of 1-R-5H-benzo[d]pyrrolo[2,1-b][1,3]oxazines and 3a-R-2,3,3a-trihydro-5H-benzo[d]pyrrolo[2 ...
Amalʼchieva, Olga A., Grinev, Vyacheslav Sergeevich, Демешко, Илья Александрович, Yegorova, Alevtina Yu.   +3 more
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Cyclization of Hydrazones of 2-Acetyl-1-naphthol and 1-Acetyl-2-naphthol with Triphosgene. Synthesis of Spiro Naphthoxazine Dimers

Molecules, 2009
Cyclization of hydrazones derived from 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene gave naphtho[1,2-e]-1,3-oxazines, naphtho[2,1-e]-1,3-oxazines or their spiro dimers depending on the molar ratio of triphosgene used for the cyclization.
Hamad Zaid Alkhathlan, Sara Abdullah Al-Mazroa, Ahmed Amine Mousa, Mohammed Ali Al-Saad, Abdullah Mohammed Al-Majid, Abdullah Saad Al-Bogami   +5 more
doaj   +1 more source