Results 11 to 20 of about 5,225 (230)

Iodination of carbohydrate-derived 1,2-oxazines to enantiopure 5-iodo-3,6-dihydro-2H-1,2-oxazines and subsequent palladium-catalyzed cross-coupling reactions [PDF]

Beilstein Journal of Organic Chemistry, 2016
Iodination of carbohydrate-derived 3,6-dihydro-2H-1,2-oxazines of type 3 using iodine and pyridine in DMF furnished 5-iodo-substituted 1,2-oxazine derivatives 4 with high efficacy. The alkenyl iodide moiety of 1,2-oxazine derivatives syn-4 and anti-4 was
Michal Medvecký, Igor Linder, Luise Schefzig, Hans-Ulrich Reissig, Reinhold Zimmer   +4 more
doaj   +3 more sources

SUBSTITUTED 4-NITROSOPYRAZOLES IN THE DIELS-ALDER REACTION

Siberian Journal of Life Sciences and Agriculture, 2021
Background. 4-Nitrosopyrazoles have become widespread in the pharmaceutical industry and in chemistry due to their high reactivity and biological activity. However, the interaction of 3,5-substituted 4-nitroso-1H-pyrazoles with diene hydrocarbons has not
Darya S. Volkova, Arkadiy A. Popov, Evgeny V. Root, Alexey A. Kukushkin, George A. Suboch   +4 more
doaj   +1 more source

Interaction of 3H-furan-2-ones and 4-oxobutanoic acids with 2-(aminophenyl)methanol [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2022
Reactions of 4-oxobutanoic acids as well as their cyclic analogues 3H-furan-2-ones with 1,3-binucleophilic reagent (2-aminophenyl) methanol lead to the formation of 1-R-5H-benzo[d]pyrrolo[2,1-b][1,3]oxazines and 3a-R-2,3,3a-trihydro-5H-benzo[d]pyrrolo[2 ...
Amalʼchieva, Olga A., Grinev, Vyacheslav Sergeevich, Демешко, Илья Александрович, Yegorova, Alevtina Yu.   +3 more
doaj   +1 more source

1,4-Oxazine

Chemical Communications, 2013
The fundamental heterocyclic compound 1,4-oxazine has been generated using FVP. It is the first parent heterocycle among all the possible isomeric oxazines, thiazines and their heavier atom analogues to be characterised spectroscopically, and is shown to exist in solution entirely as the 4H-isomer.
Aitken, R Alan, Aitken, Kati Marianne, Carruthers, Phillip G, Jean, Marc-Alexandre, Slawin, Alexandra Martha Zoya   +4 more
openaire   +5 more sources

Cyclization of Hydrazones of 2-Acetyl-1-naphthol and 1-Acetyl-2-naphthol with Triphosgene. Synthesis of Spiro Naphthoxazine Dimers

Molecules, 2009
Cyclization of hydrazones derived from 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene gave naphtho[1,2-e]-1,3-oxazines, naphtho[2,1-e]-1,3-oxazines or their spiro dimers depending on the molar ratio of triphosgene used for the cyclization.
Hamad Zaid Alkhathlan, Sara Abdullah Al-Mazroa, Ahmed Amine Mousa, Mohammed Ali Al-Saad, Abdullah Mohammed Al-Majid, Abdullah Saad Al-Bogami   +5 more
doaj   +1 more source

Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase [PDF]

, 2014
Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). The test revealed that the newly synthesized compounds had potent inhibition towards both 5-LOX and AChE in lower micro molar ...
Basappa, ., Ioffe, S.L., Nanjunda Swamy, S., Nirvanappa, A.C., Rangappa, K.S., Sukhorukov, A.Y., Swamy, J.   +6 more
core   +1 more source

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

Applied Sciences, 2023
Currently, 1-amidoalkyl-2-naphthol derivatives are of increasing interest due to their biological activities and further use in the preparation of other important bioactive molecules, such as aminoalkyl naphthols and oxazines.
Hristo Petkov, Svilen P. Simeonov
doaj   +1 more source

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2 [PDF]

, 2015
In the present study, we used solution combustion synthesis-bismuth oxide (Bi2O3) as catalyst for the simple and efficient synthesis of 1,2-oxazine based derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazoles, 1-arylpiperazine and carbazoles.
Baburajeev, C.P., Basappa, ., Bender, A., Chandra, ., Fuchs, J.E., Jagadish, S., Madegowda, M., Mason, D.J., Mohan, C.D., Rangappa, K.S., Rangappa, S., Sharath Kumar, K.S., Srinivas, V., Sukhorukov, A.Y.   +13 more
core   +1 more source

N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

Frontiers in Pharmacology, 2018
Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Therefore,
Chakrabhavi Dhananjaya Mohan, Hanumantharayappa Bharathkumar, Dukanya, Shobith Rangappa, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Atanu Bhattacharjee, Peter E. Lobie, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Basappa, Basappa, Kanchugarakoppal S. Rangappa, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar, Alan Prem Kumar   +19 more
doaj   +1 more source

Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis [PDF]

, 2010
Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of
Amin Ismael, Araujo, Brigas, Butler, Butler, Catalan, Cristiano, Elguero, Gómez-Zavaglia, Gómez-Zavaglia, Katritzky, Koldobskii, Koldobskii, Luís Miguel Teodoro Frija, Maier, Maria Lurdes Santos Cristiano, Moore, Ostrovskii, Ostrovskii   +18 more
core   +2 more sources