Results 11 to 20 of about 8,948 (229)

Gold(I)-Catalyzed Synthesis of 4H-Benzo[d][1,3]oxazines and Biological Evaluation of Activity in Breast Cancer Cells

ACS Omega, 2022
The first gold(I)-catalyzed cycloisomerization procedure applied to the synthesis of substituted 4H-benzo[d][1,3]oxazines has been developed starting from N-(2-alkynyl)aryl benzamides.
Luis A. Segura-Quezada, Karina R. Torres-Carbajal, N. Mali, D. Patil, Mauricio Luna-Chagolla, Rafael Ortíz‐Alvarado, Melissa Tapia‐Juárez, Ixamail Fraire-Soto, Jorge Gustavo Araujo-Huitrado, A. J. Granados‐López, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Estrada, Yamilé López-Hernández, J. A. López, L. Chacón-García, C. Solorio-Alvarado   +15 more
semanticscholar   +2 more sources

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo [PDF]

PLoS ONE, 2016
Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and inflammatory bowel diseases.
Anilkumar C. Nirvanappa, C. D. Mohan, S. Rangappa, H. Ananda, A. Sukhorukov, M. Shanmugam, M. S. Sundaram, S. C. Nayaka, K. Girish, A. Chinnathambi, M. Zayed, S. Alharbi, G. Sethi, Basappa, K. Rangappa   +14 more
semanticscholar   +2 more sources

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

Beilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
A. Khlebnikov, M. Novikov, Y. G. Gorbunova, E. Galenko, Kirill I Mikhailov, V. V. Pakalnis, M. Avdontceva   +6 more
semanticscholar   +2 more sources

Cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects

Toxicology in Vitro, 2017
Walter JOSÉ Peláez, Ana Carolina Araújo Mengarda, Rivelilson Freitas   +2 more
exaly   +2 more sources

Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Biomedicines, 2023
Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure ...
Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +10 more
doaj   +1 more source

Self-Organization in Dilute Aqueous Solutions of Thermoresponsive Star-Shaped Six-Arm Poly-2-Alkyl-2-Oxazines and Poly-2-Alkyl-2-Oxazolines

Polymers, 2021
The behavior of star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines in aqueous solutions on heating was studied by light scattering, turbidimetry and microcalorimetry.
T. Kirila, A. Smirnova, V. Aseyev, A. Tenkovtsev, H. Tenhu, A. Filippov   +5 more
semanticscholar   +1 more source

Switchable Coumarins for Ratiometric pH Sensing

Frontiers in Materials, 2021
A fluorescent chromophore and a pH-sensitive heterocycle were integrated within a single covalent skeleton to generate four molecular switches with ratiometric fluorescence response.
Mercedes M. A. Mazza, Francesca Cardano, Francesca Cardano, Francesca Cardano, James D. Baker, Silvia Giordani, Silvia Giordani, Françisco M. Raymo   +7 more
doaj   +1 more source

Use of Phenyl Formate as a CO Surrogate for the Reductive Cyclization of Organic Nitro Compounds to Yield Different N-Heterocycles: Avoiding the Use of Autoclaves and Pressurized Gases

Chemistry Proceedings, 2022
The reductive cyclization of different organic nitro compounds by carbon monoxide, catalyzed by transition metal complexes, is a very efficient and clean strategy for the synthesis of many N-heterocycles.
Fabio Ragaini, Francesco Ferretti, Manar Ahmed Fouad   +2 more
doaj   +1 more source

Oxazinethione Derivatives as a Precursor to Pyrazolone and Pyrimidine Derivatives: Synthesis, Biological Activities, Molecular Modeling, ADME, and Molecular Dynamics Studies

Molecules, 2021
In this study, we used oxazinethione as a perfect precursor to synthesize new pyrimidine and pyrazole derivatives with potent biological activities. Biological activities were determined for all compounds against A. flavus, E. coli, S.
Magda H. Abdellattif, Mohd Shahbaaz, M. M. H. Arief, Mostafa A. Hussien   +3 more
doaj   +1 more source

Cycloaddition of 4-Acyl-1H-pyrrole-2,3-diones Fused at [e]-Side and Cyanamides: Divergent Approach to 4H-1,3-Oxazines

Molecules, 2022
4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles.
Ekaterina E. Khramtsova, Aleksandr D. Krainov, Maksim V. Dmitriev, Andrey N. Maslivets   +3 more
doaj   +1 more source