Results 221 to 230 of about 13,917,494 (361)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Liver Abscess: Think Outside the Box. [PDF]

Cureus
Charisi K, Terzaki M, Bangeas A, Taparkou A, Papadimitriou E, Karypidou E, Kouroupis D, SidiropouIou MS, Pyrpasopoulou A, Roilides E, Farmaki E.   +10 more
europepmc   +1 more source

In crystalloactivity tests with latent apple tyrosinase and two mutants reveal the importance of the mutated sites for polyphenol oxidase activity [PDF]

, 2017
Ioannis Kampatsikas, Aleksandar Bijelic, Matthias Pretzler, Annette Rompel   +3 more
openalex   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

The value of DHR-enzyme-linked immunosorbent assay in the diagnosis of chronic granulomatous disease by detecting NADPH oxidase complex activity. [PDF]

Front Pediatr
Xiaohui W, Shunying Z, Xiaoyan Z, Xiaolei T, Yuelin S, Jinrong L, Huimin L, Hui L, Haiming Y.   +8 more
europepmc   +1 more source

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

Integrated Blood Multiparameter Precise Sensing System for Economical, Rapid, and Accurate Detection of Blood Biochemical Indicators: From Centrifugation to Sensing. [PDF]

ACS Omega
Chen Y, Yang C, Yang C, Liu Z, Kao H, Chen HJ, Tang P.   +6 more
europepmc   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Neutrophil extracellular traps induced by Haemonchus contortus excretory-secretory proteins varies among goats, gerbils, and mice. [PDF]

Parasit Vectors
Tan Y, Cao S, Memon MA, Wen Z, Chen C, Feng J, Song X, Xu L, Lu M, Yan R.   +9 more
europepmc   +1 more source

The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells.

Proceedings of the National Academy of Sciences of the United States of America, 1999
D. Maxwell, Yong Wang, L. Mcintosh
semanticscholar   +1 more source