Results 221 to 230 of about 587,820 (334)

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

Advanced Science, EarlyView.
The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi, Jing Li, Shuai Li, Jing Li, Han Wang, Lei Yang, Xinyang Tan, Zhichang Zhao, Guanghua Luo, Maofeng Jing, Ary A. Hoffmann, Jichao Fang, Rui Ji   +12 more
wiley   +1 more source

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study explores the role of Mitotic Spindle Positioning (MISP) as a key inhibitor of ferroptosis in non‐small cell lung cancer (NSCLC). MISP upregulation in NSCLC tissues leads to ferroptosis resistance, promoting cell proliferation. Mechanistically, MISP suppresses Hippo signaling via MST1/2 kinases, activating YAP and enhancing SLC7A11 expression,
Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo   +6 more
wiley   +1 more source

Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat. [PDF]

, 1983
G D Luk, T. M. Bayless, Stephen B. Baylin   +2 more
openalex   +1 more source

Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development

Advanced Science, EarlyView.
Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu, Min Feng, Yi Chen, Hong‐Lin Jia, Qi Zhang, Ming Tong, Yan‐Xi Li, Yu Zhao, Xin‐Xin Liu, Shi‐Feng Cao, Zheng‐kai Wang, Hou‐wei Li, Xue Liu, Yan Zhang   +13 more
wiley   +1 more source

Testing the utility of mitochondrial cytochrome oxidase subunit 1 sequences for phylogenetic estimates of relationships between crane (Grus) species

, 2011
Dan‐Na Yu, R. Chen, Hubdar Ali Kaleri, Bing Jiang, Haoxin Xu, Wen-Jin Du   +5 more
openalex   +1 more source

Multifunctional Conductive Nanofibers for Self‐Powered Glucose Biosensors

Advanced Science, EarlyView.
This work develops a novel self‐powered glucose biosensor using polycaprolactone/polypyrrole/graphene oxide (PCL/PPy/GO) nanofibers integrated with a triboelectric nanogenerator. The system achieves high glucose detection sensitivity and generates 63 V from motion, combining robust mechanical strength with eco‐friendly energy harvesting.
Seda Gungordu Er, Rameesh Bulathsinghala, Selvinaz Burcu Kizilates, Bing Li, Rucchi Ryan, Tanveer A. Tabish, Ishara Dharmasena, Mohan Edirisinghe   +7 more
wiley   +1 more source

Safety evaluation of the food enzyme glucose oxidase from the non-genetically modified <i>Aspergillus tubingensis</i> strain GOX. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Sramkova M, Van Loveren H, Vernis L, Aguilera J, Andryszkiewicz M, Pesce F, Marini E, Criado A, Liu Y.   +19 more
europepmc   +1 more source

Single Test‐Based Diagnosis and Subtyping of Pulmonary Hypertension Caused by Fibrosing Mediastinitis Using Plasma Metabolic Analysis

Advanced Science, EarlyView.
Pulmonary hypertension caused by fibrosing mediastinitis has a five‐year survival rate of just 56%. Current diagnostic approaches are complex for patients with mobility limitations and can lead to misdiagnoses due to their nonspecific clinical features.
Yating Zhao, Chunmeng Ding, Hongling Su, Aqian Wang, Aiping Tang, Hongfan Zhao, Ya Ma, Min Zhang, Wanshan Liu, Ruimin Wang, Ziyue Zhang, Shouzhi Yang, Dingyitai Liang, Yida Huang, Kun Qian, Lin Huang, Qihua Fu, Yunshan Cao   +17 more
wiley   +1 more source

Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease. [PDF]

Nat Commun
Glaros E, Foot J, Rayner B, Schilter H, Zhang Y, Paumann-Page M, Teixeira MM, Jarolimek W, Thomas SR.   +8 more
europepmc   +1 more source