Results 251 to 260 of about 595,509 (339)

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF‐1 Pathway in Polycystic Ovary Syndrome

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
High‐end normal hemoglobin levels are associated with an increased odds of polycystic ovary syndrome (PCOS), potentially through a mechanism of elevating testosterone levels involving the hypoxia‐inducible factor 1 (HIF‐1) pathway. These findings provide novel insights into the pathophysiology of PCOS and highlight that hemoglobin levels may serve as a
Guiquan Wang   +13 more
wiley   +1 more source

Iron Phthalocyanine as a Catalyst for the Aerobic Oxidation of Hydroquinone to 1,4-Benzoquinone. A Simple Test for Catalytic 'Oxidase' Activity. [PDF]

open access: gold, 1993
Helena Grennberg   +9 more
openalex   +1 more source

RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
This study elucidates the role of RNASET2 in inhibiting the metastasis of HCC. RNASET2 preferentially cleaves RNA into uridine, which contributes to the salvage synthesis of UTP and the glucuronidation of bile acids, thereby maintaining a balance in cholesterol metabolism. This process is followed by the degradation of MET in the lysosome.
Yanquan Xu   +14 more
wiley   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li   +21 more
wiley   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

open access: yesAdvanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Evaluation of Antioxidant, Xanthine Oxidase-Inhibitory, and Antibacterial Activity of Syzygium cumini Linn. Seed Extracts. [PDF]

open access: yesPlants (Basel)
Pandey J   +7 more
europepmc   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

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