Results 271 to 280 of about 14,049,097 (359)

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Photoinduced Inhibition of Neutrophil Extracellular Traps Formation by Dichromatic Light Irradiation. [PDF]

Curr Issues Mol Biol
Mamatkulov K, Arynbek Y, Le HD, Vorobjeva N, Arzumanyan G.   +4 more
europepmc   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Extracts, Fractions, and Subfractions from Purple-Orange Sweet Potato (<i>Ipomoea batatas</i> L.): Xanthine Oxidase Inhibitory Potential and Antioxidant Properties. [PDF]

Molecules
Suhendy H, Insanu M, Fidrianny I.
europepmc   +1 more source

Top‐Down Fabricated Wood‐Derived Pressure and Strain Sensors: A Review

Advanced Science, EarlyView.
This review focuses on wood‐derived pressure/strain sensors fabricated via top‐down strategies. It analyzes wood's structural composition, examines processing techniques, discusses sensor types and sensing mechanisms, and reviews existing research. The article concludes with future directions for enhancing performance and scalability.
Yi Ren, Fuyao Liu, Yanan Zhong, Shengbo Ge, Zhipeng Shi, Siling Lin, Hongli Song, Yingying Zhang, Wei Fan   +8 more
wiley   +1 more source

What is uric acid concentration in urine in patients with uric acid kidney stones? - a case study. [PDF]

Biochem Med (Zagreb)
Šálek T, Musil P, Zlatníková I.
europepmc   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Antimicrobial resistance and molecular characterization of ESBL-producing Enterobacterales from Parirenyatwa Hospital wastewater in Harare. [PDF]

JAC Antimicrob Resist
Marembo T, Chirenda C.
europepmc   +1 more source

Iron Single‐Atom Catalyzed N‐Alkylation of Amines with Alcohols via Solvent‐Free Borrowing Hydrogen Strategy

Advanced Science, EarlyView.
An innovative iron‐based single‐atom catalyst (FeSA@N‐G) with Fe1–N4 coordination is presented, synthesized through a simple and scalable method. It exhibits exceptional activity and selectivity in N‐alkylation via the borrowing hydrogen strategy under solvent‐free conditions, producing water as the only by‐product. Achieving record TOF (413.1 h-1) and
Arun D. Kute, Hanumant B. Kale, Priti Sharma, Srinivasu Kancharlapalli, Gajanan Y. Shinde, Ruchi Chauhan, Ajay K. Singh, Shan Jiang, Jeffrey T. Miller, Radek Zboril, Yifeng Wang, Manoj B. Gawande   +11 more
wiley   +1 more source

Haploinsufficiency of the Tyrosine Hydroxylase Gene in the Inbred C57BL/6J Strain Alters Behavior, Immunity, and Oxidative Stress, Especially After Acute Stress. [PDF]

Int J Mol Sci
Félix J, Garrido A, De la Fuente M.
europepmc   +1 more source