Results 81 to 90 of about 7,572,002 (293)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2012 A simple, sensitive and accurate spectrophotometric method of determination of Sulfacetamide (SAC) in pure form and pharmaceutical formulation. The method is based on the formation of (SAC) complex.
Ayad M.R. Raauf +2 more
doaj +1 more source
Studies in Oxidation-Reduction
NatureTHIS bulletin, obtainable for a mere half a dollar, consists of reprints of the masterly series researches published by W. Mansfield Clark and his associates from 1923 onwards. Twelve pages supplementary notes have been included.
W., Mansfield, Clark
semanticscholar +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
MicroorganismsIron, Earth’s most abundant redox-active metal, undergoes both abiotic and microbial redox reactions that regulate the formation, transformation, and dissolution of iron minerals.
Lingyu Hou +6 more
doaj +1 more source
On the mechanism of oxidation-reduction potential
, 1927 The phenomena of oxidation-reduction potential are becoming increasingly important in the study of biological oxidation processes. Unfortunately, however, the application of the results obtained from studies on potential to such processes has been ...
M. Dixon
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Investigating the role of environmental conditions in the dispersion of elements (major, minor and trace) using geochemical interpretations and models in the sedimentary deposits of Qalikuh, Lorestan [PDF]
علوم زمین خوارزمیOil shales, as an important hydrocarbon source, require careful investigation in terms of the distribution of various elements. Geochemical models are a powerful tool for understanding the distribution of elements and the factors affecting them, and help
Amirsaeid Hosseini +3 more
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