The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins+2 more
wiley +1 more source
Does diminished ovarian reserve impact oxidation-reduction potential in follicular fluid? [PDF]
Le MT, Nguyen ND, Dang HNT, Nguyen QHV.
europepmc +1 more source
OXIDATION-REDUCTION POTENTIALS OF THE METMYOGLOBIN-MYOGLOBIN SYSTEM
John Fuller Taylor, Vincent E. Morgan
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Oxidation-Reduction Potentials in Relation to the Growth of an Aerobic Form of Bacteria [PDF]
W. P. Allyn, I. L. Baldwin
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Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez+3 more
wiley +1 more source
Effect of Storage Temperature and Storage Time on the pH and Oxidation-Reduction Potential of Commercial Oral Moisturizers. [PDF]
Murakami M+4 more
europepmc +1 more source
In situ measurements of oxidation-reduction potential and hydrogen peroxide concentration as tools for revealing LPMO inactivation during enzymatic saccharification of cellulose. [PDF]
Kadić A+4 more
europepmc +1 more source
THE INITIATION OF GROWTH OF CERTAIN FACULTATIVE ANAEROBES AS RELATED TO OXIDATION-REDUCTION PROCESSES IN THE MEDIUM [PDF]
René Dubos
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