Results 41 to 50 of about 7,272,521 (356)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Application of oxidation-reduction potential in microbial fermentation [PDF]

open access: yesZhongguo niangzao
Oxidation-reduction potential (ORP), as a highly sensitive fermentation parameter that can monitor the fermentation status in real time, can be applied to fermentation by overcoming the limitations of the application of dissolved oxygen electrodes under ...
LI Zixiang, YI Dong, JIANG Shuiqin, CHEN Daijie, TAN Jun
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Development of Interactive E-Module on Oxidation-Reduction Concept

open access: yesJTK (Jurnal Tadris Kimiya), 2021
This research aims to develop an interactive e-module on redox concept. Research and Development (R&D) method was used in this study with a Plomp model. This model included three phases: preliminary, prototype or development, and assessment.
Rabiatul Adawiyah   +2 more
doaj   +1 more source

General technoeconomic analysis for electrochemical coproduction coupling carbon dioxide reduction with organic oxidation

open access: yesNature Communications, 2019
Electrochemical processes coupling carbon dioxide reduction reactions with organic oxidation reactions are promising techniques for producing clean chemicals and utilizing renewable energy. However, assessments of the economics of the coupling technology
Jonggeol Na   +9 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Manganese and iron reduction dominate organic carbon oxidation in surface sediments of the deep Ulleung Basin, East Sea [PDF]

open access: yesBiogeosciences, 2017
Rates and pathways of benthic organic carbon (Corg) oxidation were investigated in surface sediments of the Ulleung Basin (UB) characterized by high Corg contents ( >  2.5 %, dry wt.) and very high contents of Mn oxides ( >  200 µmol cm−3) and Fe ...
J.-H. Hyun   +6 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

open access: yesFEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Determining the oxidative stability and quality of tiger nut (Cyperus esculentus) oil and its antioxidant activity during microwave heating

open access: yesRevista Española de Nutrición Humana y Dietética, 2018
Introduction: The emphasis on high-oleic vegetable oils is prominent in human communities all over the world. That being said, the high level of monounsaturated fatty acid (oleic acid) in tiger nut (Cyperus esculentus) oil shows that it is resistant to ...
Atoosa Sobhani   +3 more
doaj   +1 more source

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