Results 51 to 60 of about 391,773 (316)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

High Temperature Erosion- Oxidation Behavior of Nickel- Based Alloys Containing Mo in Fluidized Bed Waste Incineration

Journal of Advanced Materials in Engineering, 2020
High-temperature erosion-oxidation behavior of nickel-based alloys containing 0-7 wt.% Mo in fluidized bed waste incineration conditions was studied. A stream of hot condensed air with a flow rate of 25 L/min caused hot silica sand (700 °C) mixed with 0 ...
M. Emami, S. Hayashi
doaj  

Effect of the dietary fat quality on insulin sensitivity. [PDF]

, 2008
Recent evidence shows that specific fatty acids affect cell metabolism, modifying the balance between fatty acid oxidation and lipogenesis. These effects may have important implications in addressing the present epidemic of nutrition-related chronic ...
Aguirre, Carolina A, Uauy Dagach-Imbarack, Ricardo, Galgani Fuentes, José, Díaz Bustos, Erik, Aguirre, Carolina A., Galgani, José E, Uauy, Ricardo D, Díaz, Erik O   +7 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Effect of Aluminizing and Laser Shock Peening Treatments on the High-Temperature Oxidation Resistance of AISI 321 Stainless Steel for Solar Thermal Power Heat Exchanger

Chinese Journal of Mechanical Engineering
The high-temperature oxidation resistance of AISI 321 stainless steel used in solar thermal power heat exchangers determines its service life. In this study, aluminizing and subsequent laser shock peening (LSP) treatments were employed to improve the ...
Wei Li, Wenyang Qin, Dapeng Jiang, Guowei Bo, Song Ni, Hui Chen, Yilin Zhao, Weiying Huang, Xulong Peng, Jianjun He, Yanjie Ren, Cong Li, Libo Zhou, Shengde Zhang, Jian Chen   +14 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quaternary diborides—improving the oxidation resistance of TiB2 ± z coatings by disilicide alloying

Materials Research Letters, 2023
To overcome the limited oxidation resistance of the emerging class of transition metal borides, we suggest within this study novel quaternary diborides, Ti-TM-Si-B2 ± z (TM = Ta, Mo), achieving the compromise between excellent oxidation resistance and ...
Ahmed Bahr, Oskar Beck, Thomas Glechner, Alexander Grimmer, Tomasz Wojcik, Philip Kutrowatz, Jürgen Ramm, Oliver Hunold, Szilard Kolozsvári, Peter Polcik, Eleni Ntemou, Daniel Primetzhofer, Helmut Riedl   +12 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source