Results 61 to 70 of about 361,906 (268)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation of Properties of Crofer Stainless Steel Produced by Mechanical Alloying for Using as Interconnect Plates of Solid Oxide Fuel Cells

Journal of Advanced Materials in Engineering, 2016
This study has examined the properties of Crofer 22APU stainless steel produced by mechanical alloying for using as interconnect plates in solid oxide fuel cells.This alloy was produced by mixing the source powders and mechanical alloying for 40 hours ...
M. Rezvani, K. Raeissi, F.L. Karimzadeh
doaj   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Research on the high-temperature oxidation properties of high-Mn and low-Ni austenitic stainless steel containing an aluminizing layer

Journal of Materials Research and Technology
High manganese (Mn) austenitic stainless steel substitutes expensive nickel (Ni) with more affordable Mn, thereby reducing production costs. However, its resistance to high-temperature oxidation is significantly compromised due to the formation of ...
Yongjie Deng, Feipeng Qin, Yanjun Zhao, Jinyu Yu, Xiangxin Wei, Feng Wei   +5 more
doaj   +1 more source

Microstructure, phase composition and oxidation behavior of porous Ti-Si-Mo intermetallic compounds fabricated by reactive synthesis

High Temperature Materials and Processes, 2020
Porous Ti-Si-Mo intermetallic compounds were fabricated by reactive synthesis using C7H10N2O2S as a foaming agent. The effects of Mo content on the microstructure, phase composition and oxidation behavior were investigated.
Ru Jinming, Wang Ya, Wang Yuemei, Xu Xiaojing   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Dietary vitamin E improves meat quality and antioxidant capacity in broilers by upregulating the expression of antioxidant enzyme genes

Journal of Applied Animal Research, 2018
A total of 240 one-day-old broiler chicks were divided into 3 treatments with 4 replicates of 20 birds. The birds were fed a corn–soybean meal diet supplemented with 0, 100, and 200 mg/kg vitamin E (VE), respectively.
Z. Y. Niu, Y. N. Min, F. Z. Liu
doaj   +1 more source

An alternative route to nitric oxide resistance [PDF]

Molecular Microbiology, 2010
Summary Vibrio fischeri is a bioluminescent bacterium that enters into a symbiosis with the bobtail squid Euprymna scolopes. The bacterium colonizes a specialized light organ, in which it generates light that might help the squid to hide its silhouette from animals beneath it.
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source