Results 81 to 90 of about 391,773 (316)

Role of Cr additions in enhancing wear and oxidation resistance of (Mo1-xCrx)Si-2 nanocrystalline films

, 2014
In order to explore the effects of Cr alloying on the wear and oxidation resistance of MoSi2 films, four kinds of (Mo1-xCrx)Si-2 (x=0, 0.05, 0.10 and 0.15) nanocrystalline films of differing Cr contents were fabricated onto Ti6Al4V substrates by a double
Munroe P, Li ZY(李正阳), Xu, J (reprint author), Nanjing Univ Aeronaut & Astronaut, Dept Mat Sci & Engn, 29 Yudao St, Nanjing 210016, Jiangsu, Peoples R China., Xie ZH, Xu J   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Elevated Temperature Oxidation and Corrosion of a Titanium Aluminide Alloy [PDF]

, 1997
Titanium aluminides are being developed to expand the temperature capability of titanium alloys with maximum service temperatures around 700*C. These materials also have the ability to replace nickel superalloys with potential applications in the high ...
Leggett, Jonathan, Leggett, J.
core  

Nitric oxide‐enhanced resistance to oral candidiasis

Immunology, 2001
SummaryA murine model of oral candidiasis was used to show that nitric oxide (NO) is involved in host resistance to infection with Candida albicans in infection‐‘resistant’ BALB/c and infection‐‘prone’ DBA/2 mice. Following infection, increased NO production was detected in saliva. Postinfection samples of saliva inhibited the growth of yeast in vitro.
Elahi, S., Pang, G., Ashman, R. B., Clancy, R.   +3 more
openaire   +6 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of Properties of Crofer Stainless Steel Produced by Mechanical Alloying for Using as Interconnect Plates of Solid Oxide Fuel Cells

Journal of Advanced Materials in Engineering, 2016
This study has examined the properties of Crofer 22APU stainless steel produced by mechanical alloying for using as interconnect plates in solid oxide fuel cells.This alloy was produced by mixing the source powders and mechanical alloying for 40 hours ...
M. Rezvani, K. Raeissi, F.L. Karimzadeh
doaj   +2 more sources

Research on the high-temperature oxidation properties of high-Mn and low-Ni austenitic stainless steel containing an aluminizing layer

Journal of Materials Research and Technology
High manganese (Mn) austenitic stainless steel substitutes expensive nickel (Ni) with more affordable Mn, thereby reducing production costs. However, its resistance to high-temperature oxidation is significantly compromised due to the formation of ...
Yongjie Deng, Feipeng Qin, Yanjun Zhao, Jinyu Yu, Xiangxin Wei, Feng Wei   +5 more
doaj   +1 more source

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria. [PDF]

, 2002
We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa.
Fivelman, Quinton L, Pasvol Geoffrey, Adagu Ipemida S, Butcher, Geoffrey A, Adagu, Ipemida S, Warhurst David C, Butcher Geoffrey A, David C Warhurst, Geoffrey Pasvol, Quinton L Fivelman, Warhurst, David C, Fivelman Quinton L, Pasvol, Geoffrey, Ipemida S Adagu, Beier, John, Geoffrey A Butcher   +15 more
core   +1 more source

Monolayer Doping of Si with Improved Oxidation Resistance

ACS Applied Materials & Interfaces, 2016
In this article, the functionalization of planar silicon with arsenic- and phosphorus-based azides was investigated. Covalently bonded and well-ordered alkyne-terminated monolayers were prepared from a range of commercially available dialkyne precursors using a well-known thermal hydrosilylation mechanism to form an acetylene-terminated monolayer.
O'Connell, John, Collins, Gillian, McGlacken, Gerard P., Duffy, Ray, Holmes, Justin D.   +4 more
openaire   +3 more sources