Results 211 to 220 of about 13,910,228 (354)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Covalent Bonding Between Ir and High-Oxidation State Sb Constrained by Quinoline Scaffolds. [PDF]

Inorg Chem
Kong F, Webber CK, Kumawat J, Quirion KP, Ou X, Dickie DA, Ess DH, Gunnoe TB.   +7 more
europepmc   +1 more source

The highest oxidation state observed in graphene-supported sub-nanometer iron oxide clusters. [PDF]

Commun Chem, 2023
Perco D, Loi F, Bignardi L, Sbuelz L, Lacovig P, Tosi E, Lizzit S, Kartouzian A, Heiz U, Baraldi A.   +9 more
europepmc   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source

Gold-Mediated Base Pairs in Nucleic Acids: Selective Coordination to Natural and Thiocarbonyl-Modified Cytosines Dependent upon the Oxidation State of Gold. [PDF]

Chembiochem
Kosugi K, Sugawara A, Iwase E, Park H, Fujiwara S, Kanazawa H, Ono A, Kondo J.   +7 more
europepmc   +1 more source

Oxidation State Tuning of Room Temperature Phosphorescence and Delayed Fluorescence in Phenothiazine and Phenothiazine-5,5-dioxide Dimers. [PDF]

Chemistry, 2023
Wright IA, Etherington MK, Batsanov AS, Monkman AP, Bryce MR.   +4 more
europepmc   +1 more source

A re-assessment of the oxidation state of iron in MORB glasses

, 2018
A. Berry, G. Stewart, H. O’Neill, G. Mallmann, J. Mosselmans   +4 more
semanticscholar   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

The Ammonia Oxidising Archaeon Nitrosopumilus maritimus Does Not Alter Iodine Oxidation State in Oxic Seawater. [PDF]

Environ Microbiol Rep
Webb AL, Oudova-Rivera B, Ward M, Carpenter LJ, Lehtovirta-Morley LE, Chance R.   +5 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source