Results 191 to 200 of about 63,046 (336)

Antinociception by the anti-oxidized phospholipid antibody E06. [PDF]

Br J Pharmacol, 2018
Mohammadi M, Oehler B, Kloka J, Martin C, Brack A, Blum R, Rittner HL.   +6 more
europepmc   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Excipient Emulsion–Based Delivery Systems for Enhancing Carotenoid Bioavailability: Advances in Formulation and Gastrointestinal Fate

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Excipient emulsion systems improve carotenoid solubilization, protect against degradation, and enhance gastrointestinal absorption through optimized formulation and digestion behavior. ABSTRACT Carotenoids are bioactive compounds that contribute to human health through antioxidant, provitamin A, and disease‐preventive effects.
Tugce Ceyhan, Elifsu Nemli, Esra Capanoglu, Merve Tomas   +3 more
wiley   +1 more source

Reduction of myocardial ischaemia–reperfusion injury by inactivating oxidized phospholipids [PDF]

, 2018
Calvin Yeang, Devin Hasanally, Xuchu Que, Ming‐Yow Hung, Aleksandra Stamenković, David P. Chan, Rakesh Chaudhary, Victoria Margulets, Andrea L. Edel, Masahiko Hoshijima, Yusu Gu, William Bradford, Nancy D. Dalton, Phuong Miu, David YC Cheung, Davinder S. Jassal, Grant N. Pierce, Kirk L. Peterson, Lorrie A. Kirshenbaum, Joseph L. Witztum, Sotirios Tsimikas, Amir Ravandi   +21 more
openalex   +1 more source

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

Advanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu, Rujia Liu, Xinyan Zhang, Xun Chen, Shuhua Yue   +4 more
wiley   +1 more source

The effects of colchicine on lipoprotein(a)- and oxidized phospholipid-associated cardiovascular disease risk. [PDF]

Eur J Prev Cardiol
Mohammadnia N, van Broekhoven A, Bax WA, Eikelboom JW, Mosterd A, Fiolet ATL, Tijssen JGP, Thompson PL, de Kleijn DPV, Tsimikas S, Cornel JH, Yeang C, El Messaoudi S.   +12 more
europepmc   +1 more source

Prostaglandin E receptor‐4 receptor mediates endothelial barrier–enhancing and anti‐inflammatory effects of oxidized phospholipids [PDF]

, 2017
Olga Oskolkova, Grzegorz Gawlak, Yufeng Tian, Yunbo Ke, Nicolene Sarich, Sophia Son, Katrin I. Andreasson, Valery N. Bochkov, Anna A. Birukova, Konstantin G. Birukov   +9 more
openalex   +1 more source

Oxidized phospholipids on alkyl-amide scaffold demonstrate anti-endotoxin and endothelial barrier-protective properties

, 2023
Olga Oskolkova, Alma Hodzic, Pratap Karki, Bernd Gesslbauer, Yunbo Ke, Dina Hofer, Juliane Gertrude Bogner‐Strauß, Jean‐Marie Galano, Camille Oger, Anna A. Birukova, Thierry Durand, Konstantin G. Birukov, Valery N. Bochkov   +12 more
openalex   +2 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source