Results 141 to 150 of about 506,293 (263)

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

High-Density Lipoprotein Suppresses Neutrophil Extracellular Traps Enhanced by Oxidized Low-Density Lipoprotein or Oxidized Phospholipids. [PDF]

Int J Mol Sci, 2022
Ohinata H, Obama T, Makiyama T, Watanabe Y, Itabe H.   +4 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats. [PDF]

Amino Acids, 2022
Narzt MS, Kremslehner C, Golabi B, Nagelreiter IM, Malikovic J, Hussein AM, Plasenzotti R, Korz V, Lubec G, Gruber F, Lubec J.   +10 more
europepmc   +1 more source

Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin

, 2012
Alejandro K. Samhan‐Arias, Jing Ji, Ольга Михайловна Демидова, Louis J. Sparvero, Weihong Feng, Vladimir A. Tyurin, Yulia Y. Tyurina, Michael W. Epperly, Anna A. Shvedova, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Andrew A. Amoscato   +12 more
openalex   +2 more sources

Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease [PDF]

, 2016
Mohamed Jalloul Nsaibia, Ablajan Mahmut, Marie‐Chloé Boulanger, Benoît J. Arsenault, Rihab Bouchareb, Serge Simard, Joseph L. Witztum, Marie‐Annick Clavel, Philippe Pîbarot, Yann Le Bossé, Sotirios Tsimikas, Patrick Mathieu   +11 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

BS23 Gender and aspirin impact generation of procoagulant oxidized phospholipids by platelets in a healthy human cohort [PDF]

, 2019
Majd Protty, Christopher J. Brasher, Victoria J. Tyrrell, Patrícia Rodrigues, Maceler Aldrovandi, Samya Obaji, Patrick Jenkins, Peter W. Collins, Valerie B. O’Donnell   +8 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value. [PDF]

Front Immunol, 2022
Li Z, Luo Z, Shi X, Pang B, Ma Y, Jin J.
europepmc   +1 more source