Results 11 to 20 of about 1,467 (85)
Oxidopamine-Induced Nuclear Alterations Quantified Using Advanced Fractal Analysis: Random Forest Machine Learning Approach [PDF]
Fractal and Fractional, 2023 Fractal analysis (FA) is a contemporary computational technique that can assist in identifying and assessing nuanced structural alterations in cells and tissues after exposure to certain toxic chemical agents.
Igor Pantic +2 more
exaly +6 more sources
Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype [PDF]
Scientific Reports, 2017 Cyclooxygenase-2 (COX-2) triggers pro-inflammatory processes that can aggravate neuronal degeneration and functional impairments in many neurological conditions, mainly via producing prostaglandin E2 (PGE2) that activates four membrane receptors, EP1-EP4.
Jae Yeol Lee +2 more
exaly +7 more sources
Definitions, 2020 An antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-Hydroxydopamine (6-HOD) can be taken up by selective adrenergic terminals, thereby causing acute degeneration of adrenergic terminals that leads to depletion of ...
semanticscholar +3 more sources
Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat [PDF]
Acta Cirurgica Brasileira, 2016 PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three
Javad Mahmoudi
exaly +3 more sources
Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation
Advanced Science, Volume 10, Issue 18, June 23, 2023., 2023 During lactation, norepinephrine (NE) levels increase in cortical bone. In response, osteocytes increase Ca2+ signaling to promote the secretion of bone resorptive extracellular vesicles and cathepsin K (Ctsk) to degrade the perilacunar area bone matrix.
Qiaoyue Guo +9 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 168-180, January 2023., 2023 The hydro‐ethanolic extract of P. granatum peel was standardized. ;The extract increased superoxide dismutase activity and thiol content, while reduced function of AchE and peroxidation of lipid in the scopolamine‐injured rat’s brain. ;P. granatum may attenuate scopolamine injury through targeting nuclear factor‐E2‐related factor 2 pathway ; Abstract ...
Mahsan Akbarian +5 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023., 2023 MicroRNAs (miRNAs) are short, noncoding RNA transcripts. Mammalian miRNA coding sequences are located in introns and exons of genes encoding various proteins. As the central nervous system is the largest source of miRNA transcripts in living organisms, miRNA molecules are an integral part of the regulation of epigenetic activity in physiological and ...
Adam Szelągowski +2 more
wiley +1 more source
Chinese Medical Journal, 2017 Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in patients is due to the disease progression ...
Si-Yue Li +8 more
doaj +1 more source
Parkinson's Disease, Volume 2012, Issue 1, 2012., 2012 We discuss the participation of mitochondrial dynamics and autophagy in the 6‐hydroxidopamine‐induced Parkinson’s disease model. The regulation of dynamic mitochondrial processes such as fusion, fission, and mitophagy has been shown to be an important mechanism controlling cellular fate.
Maria F. Galindo +5 more
wiley +1 more source
Small Molecule Inhibition of RISC Loading
ACS Chemical Biology, 2011 Argonaute proteins are the core components of the microRNP/RISC. The biogenesis and function of microRNAs and endo- and exo- siRNAs are regulated by Ago2, an Argonaute protein with RNA binding and nuclease activities.
Grace S. Tan +5 more
semanticscholar +1 more source