Results 21 to 30 of about 1,730 (92)
Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023., 2023 MicroRNAs (miRNAs) are short, noncoding RNA transcripts. Mammalian miRNA coding sequences are located in introns and exons of genes encoding various proteins. As the central nervous system is the largest source of miRNA transcripts in living organisms, miRNA molecules are an integral part of the regulation of epigenetic activity in physiological and ...
Adam Szelągowski +2 more
wiley +1 more source
Chinese Medical Journal, 2017 Background: Parkinson's disease (PD) patients with long-term levodopa (L-DOPA) treatment are suffering from severe circadian dysfunction. However, it is hard to distinguish that the circadian disturbance in patients is due to the disease progression ...
Si-Yue Li +8 more
doaj +1 more source
Parkinson's Disease, Volume 2012, Issue 1, 2012., 2012 We discuss the participation of mitochondrial dynamics and autophagy in the 6‐hydroxidopamine‐induced Parkinson’s disease model. The regulation of dynamic mitochondrial processes such as fusion, fission, and mitophagy has been shown to be an important mechanism controlling cellular fate.
Maria F. Galindo +5 more
wiley +1 more source
The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases
Advanced Science, Volume 11, Issue 16, April 24, 2024.Despite significant research efforts, the knowledge about neurodegenerative disorder pathological processes and the development of efficacious drugs are still limited due to the inability to access and reproduce the intricated microenvironment of the nervous system.
Eleonora De Vitis +7 more
wiley +1 more source
Suppressing RNA silencing with small molecules and the viral suppressor of RNA silencing protein p19
, 2015 RNA silencing is a gene regulatory and host defense mechanism whereby small RNA molecules are engaged by Argonaute (AGO) proteins, which facilitate gene knockdown of complementary mRNA targets.
Danielson, Dana C. +4 more
core +1 more source
Journal of Radiation Research and Applied SciencesObjective: To discover novel therapeutic agents for Parkinson's disease (PD) and enhance treatment efficacy, this study aimed to explore the modulatory influence of Hydroxysafflor yellow A (HSYA) governs on autophagic processes in a PD cellular model via
Qianhua Dai +3 more
doaj +1 more source
The Journal of Qazvin University of Medical Sciences, 2016 Background: Nuclease and caspase activities that promote death signals and cause apoptosis are dependent to potassium ion. Objective: The aim of this study was to investigate the effect of potassium channel blocker tetraethylammonium (TEA) on prevention
H. Haghdoost-Yazdi +5 more
doaj
The Journal of Qazvin University of Medical Sciences, 2015 Background: Nuclease and caspase enzymes activities which promote death signals and lead to apoptosis are dependent to potassium ions. Objective: The aim of this study was to determine the effect of 4-aminopyridine (4-AP) potassium channel blocker on ...
M. Sofiabadi +5 more
doaj
Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia
, 1994 The present study provides evidence for anterograde axonal transport of managanese (Mn) in the basal ganglia. Microinjections of 54Mn into rat substantia nigra or stratum revealed region-specific accumulation and retention of the isotope in globus ...
Sloot, W.N., Gramsbergen, J.B.P.
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, 1989 In the present study the neuronal source of adenosine released by K+, morphine and norepinephrine (NE) from the spinal cord was investigated. Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine ...
core