Fractal and Fractional, 2023 Fractal analysis (FA) is a contemporary computational technique that can assist in identifying and assessing nuanced structural alterations in cells and tissues after exposure to certain toxic chemical agents.
Igor Pantic +2 more
exaly +5 more sources
Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype [PDF]
Scientific Reports, 2017 AbstractCyclooxygenase-2 (COX-2) triggers pro-inflammatory processes that can aggravate neuronal degeneration and functional impairments in many neurological conditions, mainly via producing prostaglandin E2 (PGE2) that activates four membrane receptors, EP1-EP4. However, which EP receptor is the culprit of COX-2/PGE2-mediated neuronal inflammation and
Jae Yeol Lee, Qianqian Li, Xu Kang
exaly +4 more sources
Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4
Journal of Integrative NeuroscienceBackground: The main symptoms of Parkinson’s disease (PD) include olfactory impairment and tremor. Current treatment methods for PD generally have limitations such as short duration and severe side effects.
Jiahong Zhong +4 more
exaly +3 more sources
Research on Role of Connexin 36 in Pathogenesis of Rats with Levodopa-induced Dyskinesia
康复学报, 2016 Objective:To study the role of striatal connexin 36 (Cx36) in the pathogenesis of levodopa-induced dyskinesia (LID).Methods:A total of 60 SD rats were divided into the normal group, the sham operation group, the Parkinson's disease (PD) group, the ...
Bingtian ZHANG +4 more
doaj +2 more sources
Metabolic Characterization of Cellular Health Using a Multimodal Spectroscopy Technique [PDF]
, 2019 The mitochondria act as a bridge between cell metabolism and overall cell health due to the dual roles it plays in both apoptosis and as the site of mitochondrial respiration.
Rosiek, Eric
core +7 more sources
The role of adenosine monophosphate-activated protein kinase and mitogen-activated protein kinase p38 in autophagy and death induction in neuroblastoma cells treated with oxidopamine in vitro [PDF]
, 2021 Autofagija, razgradnja nepotrebnih/nefunkcionalnih unutarćelijskih komponenti u autolizozomima, kiselim organelama nastalim spajanjem autofagozoma i lizozoma, može biti citoprotektivna i citotoksična.
Arsikin Csordás, Katarina
core +5 more sources
Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation
Advanced Science, Volume 10, Issue 18, June 23, 2023., 2023 During lactation, norepinephrine (NE) levels increase in cortical bone. In response, osteocytes increase Ca2+ signaling to promote the secretion of bone resorptive extracellular vesicles and cathepsin K (Ctsk) to degrade the perilacunar area bone matrix.
Qiaoyue Guo +9 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 168-180, January 2023., 2023 The hydro‐ethanolic extract of P. granatum peel was standardized. ;The extract increased superoxide dismutase activity and thiol content, while reduced function of AchE and peroxidation of lipid in the scopolamine‐injured rat’s brain. ;P. granatum may attenuate scopolamine injury through targeting nuclear factor‐E2‐related factor 2 pathway ; Abstract ...
Mahsan Akbarian +5 more
wiley +1 more source
Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three
Siamak Reyhani-Rad, Javad Mahmoudi
doaj +2 more sources