The Evolution of Technology‐Driven In Vitro Models for Neurodegenerative Diseases
Advanced Science, Volume 11, Issue 16, April 24, 2024.Despite significant research efforts, the knowledge about neurodegenerative disorder pathological processes and the development of efficacious drugs are still limited due to the inability to access and reproduce the intricated microenvironment of the nervous system.
Eleonora De Vitis +7 more
wiley +1 more source
Influence of L-3, 4-dihydroxyphenylalanine on locomotor activities and behavioral changes in rats
Journal of Laboratory PhysiciansThe central nervous system, the kidneys, the heart, and the hormones are all greatly impacted by dopamine (DA), a neurotransmitter and one of the most significant catecholamines.
Kandra Nagavishnu +8 more
semanticscholar +1 more source
Uloga kinaze aktivirane adenozin monofosfatom i mitogenom aktivirane protein kinaze p38 u indukciji autofagije i smrti u ćelijama neuroblastoma tretiranim oksidopaminom u uslovima in vitro [PDF]
, 2021 Autofagija, razgradnja nepotrebnih/nefunkcionalnih unutarćelijskih komponenti u autolizozomima, kiselim organelama nastalim spajanjem autofagozoma i lizozoma, može biti citoprotektivna i citotoksična. U ovoj tezi ispitivana je uloga glavnog ćelijskog energetskog senzora protein kinaze aktivirane adenozin monofosfatom (AMPK) i mitogenom aktivirane ...
openaire
The Journal of Qazvin University of Medical Sciences, 2016 Background: Nuclease and caspase activities that promote death signals and cause apoptosis are dependent to potassium ion. Objective: The aim of this study was to investigate the effect of potassium channel blocker tetraethylammonium (TEA) on prevention
H. Haghdoost-Yazdi +5 more
doaj
The Journal of Qazvin University of Medical Sciences, 2015 Background: Nuclease and caspase enzymes activities which promote death signals and lead to apoptosis are dependent to potassium ions. Objective: The aim of this study was to determine the effect of 4-aminopyridine (4-AP) potassium channel blocker on ...
M. Sofiabadi +5 more
doaj
Research on Role of Connexin 36 in Pathogenesis of Rats with Levodopa-induced Dyskinesia
康复学报, 2016 Objective:To study the role of striatal connexin 36 (Cx36) in the pathogenesis of levodopa-induced dyskinesia (LID).Methods:A total of 60 SD rats were divided into the normal group, the sham operation group, the Parkinson's disease (PD) group, the ...
Bingtian ZHANG +4 more
doaj
Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology
Chemico-Biological Interactions, 2021 Oxidopamine (6-hydroxydopamine, 6-OHDA) is a toxin commonly used for the creation of experimental animal models of Parkinson's disease, attention-deficit hyperactivity disorder, and Lesch-Nyhan syndrome. Its exact mechanism of action is not completely understood, although there are many indications that it is related to the generation of reactive ...
Igor Pantic
exaly +6 more sources
Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction. [PDF]
BMC Infect DisShi X +6 more
europepmc +1 more source
Impaired cognitive and motor function are coincident with L-DOPA-induced dyskinesia in a model of Parkinson's disease. [PDF]
Sci Rep, 2023 Lelos MJ +4 more
europepmc +1 more source
Study of Intracellular Peptides of the Central Nervous System of Zebrafish (<i>Danio rerio</i>) in a Parkinson's Disease Model. [PDF]
Int J Mol SciFiametti LO +4 more
europepmc +1 more source