Results 71 to 80 of about 1,730 (92)

Neuroprotective and Antioxidant Activity of Newly Synthesized N-Pyrrolyl Hydrazide-Hydrazones in Experimental Models of Neurotoxicity In Vitro and In Vivo. [PDF]

open access: yesInt J Mol Sci
Manov M   +12 more
europepmc   +1 more source
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Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology

Chemico-Biological Interactions, 2021
Oxidopamine (6-hydroxydopamine, 6-OHDA) is a toxin commonly used for the creation of experimental animal models of Parkinson's disease, attention-deficit hyperactivity disorder, and Lesch-Nyhan syndrome. Its exact mechanism of action is not completely understood, although there are many indications that it is related to the generation of reactive ...
Igor Pantic   +2 more
exaly   +3 more sources

Gray level co-occurrence matrix algorithm as pattern recognition biosensor for oxidopamine-induced changes in lymphocyte chromatin architecture

Journal of Theoretical Biology, 2016
We demonstrate that a proapoptotic chemical agent, oxidopamine, induces dose dependent changes in chromatin textural patterns which can be quantified using the Gray level co-occurrence matrix (GLCM) method. Peripheral blood (heparin-pretreated) samples were treated with oxidopamine (6-OHDA, 6-hydroxydopamine) to achieve effective concentrations of 100,
Igor Pantic, Dejan Nesic
exaly   +3 more sources

Unveiling the potency of FDA-approved oxidopamine HBr for cervical cancer regulation and replication proteins

Medical Oncology
Cervical Cancer remains a women's health concern worldwide and ranks among the most prevalent cancers, particularly in developing countries. Many women are diagnosed with cervical cancer, with a substantial number succumbing to the disease even after the availability of vaccines and drugs.
Nawal Helmi   +2 more
exaly   +3 more sources

Multitargeted Docking, DFT-Based Optimisation, Pharmacokinetics, and MD Simulation Reveal 6-Oxidopamine HBr as a Multitargeted Inhibitor of Cervical Cancer Proteins

Current Medicinal Chemistry
Background: Cervical cancer originates in the cervix, the lower part of the uterus, and results from the uncontrolled growth of abnormal cervical cells, forming malignant tumours. It poses a major global health challenge, calling for innovative drug design strategies to enhance treatment outcomes.
Youssef Saeed, Alghamdi   +4 more
openaire   +2 more sources

Effect of chemical sympathectomy with oxidopamine on systemic blood flow in rats with acute pancreatitis.

Circulatory shock, 1986
In response to previous demonstrations that either surgical or chemical sympathectomy can ameliorate the severity of acute experimental pancreatitis, and suggestions that the benefits of sympathectomy are related to alterations in the absolute blood flow or the pattern of blood flow within the pancreas or splanchnic organs, we studied blood flow in ...
P E, Donahue   +6 more
openaire   +1 more source

Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999
To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats.The amount of dephospho-DARPP-32 was measured by a back-phosphorylation assay.In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it ...
X, Guo   +5 more
openaire   +1 more source

Stem Cell Therapy Ameliorates Bladder Dysfunction in an Animal Model of Parkinson Disease

Journal of Urology, 2012
Lysanne Campeau   +2 more
exaly  

Bone Marrow Neuropathy Prevents Hematopoietic Regeneration

Blood, 2011
Daniel Lucas   +2 more
exaly  

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