Results 21 to 30 of about 6,948 (126)

TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells

Journal of experimental & clinical cancer research : CR, 2016
Abnormal DNA methylation/demethylation is recognized as a hallmark of cancer. TET (ten-eleven translocation) family members are novel DNA demethylation related proteins that dysregulate in multiple malignances.
Zhongxue Ye, Jie Li, Xi Han, Huilian Hou, He Chen, Xia Zheng, Jiaojiao Lu, Lijie Wang, Wei Chen, Xu Li, Le Zhao   +10 more
semanticscholar   +1 more source

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)*

Journal of Biological Chemistry, 2015
Background: The role of AIF redox activity in mitochondrial respiration and redox metabolism was unknown. Results: AIF has rotenone-sensitive NADH:ubiquinone oxidoreductase activity when reconstituted with bacterial or mitochondrial membranes. Conclusion:
Mahmoud M. Elguindy, Eiko Nakamaru-Ogiso
semanticscholar   +1 more source

Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

Genome Medicine, 2016
In high-grade serous ovarian cancer (HGSOC), intrinsic and/or acquired resistance against platinum-containing chemotherapy is a major obstacle for successful treatment.
Tushar Tomar, S. de Jong, N. Alkema, Rieks L Hoekman, G. Meersma, H. Klip, A. V. D. van der Zee, G. Wisman   +7 more
semanticscholar   +1 more source

Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

Biochemical Journal, 2015
The PDI family form disulfide bridges in substrates via thiol-disulfide exchange reactions. We show in the present study that disulfide exchange can occur directly between individual PDI proteins.
O. Oka, H. Y. Yeoh, N. Bulleid
semanticscholar   +1 more source

Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

Antioxidants, 2020
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic
Ying Zhang, Y. Roh, Seong-Jeong Han, Iha Park, Hae Min Lee, Y. Ok, B. Lee, Seung-Rock Lee   +7 more
semanticscholar   +1 more source

Stellar metallicity is a key parameter for the search of Life in the Universe [PDF]

arXiv, 2022
The search for Life in the Universe generally assumes three basic life's needs: I) building block elements (i.e., CHNOPS), II) a solvent to life's reactions (generally, liquid water) and III) a thermodynamic disequilibrium. It is assumed that similar requirements might be universal in the Cosmos.
arxiv  

Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.

Biological and Pharmaceutical Bulletin, 2007
Plant lignans, such as pinoresinol diglucoside, secoisolariciresinol diglucoside and arctiin, are metabolized to mammalian lignans, enterolactone or enterodiol, by human intestinal bacteria.
Jong-Sik Jin, Yu-feng Zhao, N. Nakamura, T. Akao, N. Kakiuchi, M. Hattori   +5 more
semanticscholar   +1 more source

A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues

PLoS Comput. Biol., 2009
Cysteine (Cys) residues often play critical roles in proteins, for example, in the formation of structural disulfide bonds, metal binding, and various catalytic functions.
S. Marino, V. Gladyshev
semanticscholar   +1 more source

Enhanced Wastewater Treatment by Immobilized Enzymes

Current Pollution Reports, 2021
In the presented review, we have summarized recent achievements on the use of immobilized oxidoreductases for biodegradation of hazardous organic pollutants including mainly dyes, pharmaceuticals, phenols, and bisphenols.
J. Zdarta, K. Jankowska, Karolina Bachosz, Oliwia Degórska, Karolina Kaźmierczak, L. Nguyen, L. Nghiem, T. Jesionowski   +7 more
semanticscholar   +1 more source

Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.

European Journal of Biochemistry, 1997
Methanobacterium thermoautotrophicum (strain Marburg), which grows autotrophically on H2 and CO2, was found to contain 2-oxoisovalerate oxidoreductase (Vor) and indolepyruvate oxidoreductase (Ior) besides pyruvate oxidoreductase (Por) and 2-oxoglutarate ...
A. Tersteegen, D. Linder, R. Thauer, R. Hedderich   +3 more
semanticscholar   +1 more source