Results 21 to 30 of about 728 (69)

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Volume 45, Issue 5, Page 577-607, May 2025.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Abstracts

, 2023
Molecular Oncology, Volume 17, Issue S1, Page 1-597, June 2023.
wiley   +1 more source

Pilot Scale Production of a F420 Precursor Under Microaerobic Conditions

Biotechnology Journal, Volume 20, Issue 3, March 2025.
Graphical Abstract and Lay Summary This work studies the influence of oxygen availability on heterologous biosynthesis of the redox co‐factor FO with an engineered E. coli strain up to pilot scale. Microaerobic conditions led to a counter selection of the unwanted natural side product riboflavin and substantially increased titers of FO.
Annika Lenić, Bettina Bardl, Florian Kloss, Gundela Peschel, Ivan Schlembach, Gerald Lackner, Lars Regestein, Miriam A. Rosenbaum   +7 more
wiley   +1 more source

Structural insights and biological activities of flavonoids: Implications for novel applications

Food Frontiers, Volume 6, Issue 1, Page 218-247, January 2025.
It provides a theoretical basis for the development of new applications of flavonoids and facilitates the targeted functional molecular design and development in the food and pharmaceutical industries. In this paper, the structural characteristics of flavonoids were summarized, and the biosynthesis, digestion and absorption of flavonoids in vivo were ...
Sheng Tang, Botao Wang, Xin Liu, Wenxia Xi, Yuanyuan Yue, Xiang Tan, Junying Bai, Linhua Huang   +7 more
wiley   +1 more source

Unveiling the potentials and action mechanisms of Citri reticulatae Pericarpium as an anti‐inflammatory food

Food Frontiers, Volume 6, Issue 1, Page 163-184, January 2025.
The review summarized advances in utilizing CRP for the prevention and treatment of inflammation under various pathological conditions. The underlying mechanism has focused on polymethoxyflavones (PMFs) present in CRP and its interaction with gut microbiota. Abstract Modern lifestyle has led human body under a frequent exposure of chronic inflammation.
Yanyi Li, Ying Chen, Yue Zhou, Jiayi He, Qian Zhou, Mingfu Wang   +5 more
wiley   +1 more source

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source

Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies

MedComm, Volume 5, Issue 10, October 2024.
Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang, Jiaxuan Wu, Wenjun Zhou, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

New insights into immune cells in cancer immunotherapy: from epigenetic modification, metabolic modulation to cell communication

MedComm, Volume 5, Issue 6, June 2024.
Relationships between immune cell metabolism, epigenetics modulation, and cancer immunotherapy clinical efficiency. Epigenetic regulation (including DNA methylation, RNA methylation, histone modification, and chromatin remodeling) of immune cells can influence the differentiation and activity of immune cells, while metabolic status influences the ...
Sha Qin, Bin Xie, Qingyi Wang, Rui Yang, Jingyue Sun, Chaotao Hu, Shuang Liu, Yongguang Tao, Desheng Xiao   +8 more
wiley   +1 more source

Tailoring modifications in labrenzin synthesis: a‐la‐carte production of pathway intermediates

Microbial Biotechnology, Volume 17, Issue 1, January 2024.
In this work, we study the role of tailoring enzymes from the lab gene cluster responsible for methylation and hydroxylation of labrenzin, a pederin‐family molecule. By expressing them heterologously, we managed to produce a spectrum of differently tailored labrenzin analogs in Labrenzia sp. PHM005.
Dina Kačar, Librada M. Cañedo, Pilar Rodríguez, Carmen Schleissner, Fernando de la Calle, José Luis García, Beatriz Galán   +6 more
wiley   +1 more source

Expression patterns and prognostic value of m6A RNA methylation regulators in adrenocortical carcinoma. [PDF]

Medicine (Baltimore), 2021
Fu Y, Sun S, Bi J, Kong C, Yin L.
europepmc   +1 more source