Results 31 to 40 of about 1,328 (132)

The alternative complex III from Rhodothermus marinus – A prototype of a new family of quinol:electron acceptor oxidoreductases

, 2007
The biochemical and genetic search for a bc1 complex in Rhodothermus marinus was always fruitless; however, a functional equivalent, i.e. having quinol:cytochrome c oxidoreductase activity was characterized. Now, with the sequencing of R. marinus genome,
Teixeira, Miguel, Refojo, Patricia N., Hreggvidsson, Gudmundur O., Pereira, Manuela M., Hjorleifsdottir, Sigridur   +4 more
core   +1 more source

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source

Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies

MedComm, Volume 5, Issue 10, October 2024.
Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang, Jiaxuan Wu, Wenjun Zhou, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

Redox out of the box: catalytic versatility across NAD(p)h‐dependent oxidoreductases

The asymmetric reduction of double bonds using NAD(P)H-dependent oxidoreductases has proven to be an efficient tool for the synthesis of important chiral molecules in research and on industrial scale. These enzymes are commercially available in screening
Niese, Richard, Müller, Michael, Roth, Sebastian, Hall, Mélanie   +3 more
core   +1 more source

Is EC class predictable from reaction mechanism?

, 2012
We thank the Scottish Universities Life Sciences Alliance (SULSA) and the Scottish Overseas Research Student Awards Scheme of the Scottish Funding Council (SFC) for financial support.Background: We investigate the relationships between the EC (Enzyme ...
John BO Mitchell, Neetika Nath, Nath Neetika, Mitchell John BO, Nath, Neetika, Mitchell, John B. O.   +5 more
core   +1 more source

Change in cofactor specificity of oxidoreductases by adaptive evolution of an escherichia coli nadph-auxotrophic strain

, 2021
The nicotinamide cofactor specificity of enzymes plays a key role in regulating metabolic processes and attaining cellular homeostasis. Multiple studies have used enzyme engineering tools or a directed evolution approach to switch the cofactor preference
Döring, V., Bar-Even, Arren, Arren Bar-Even, Dubois, I., Madeleine Bouzon, Liliana Calzadiaz Ramirez, Döring, Volker, Stoffel, Gabriele, Erb, T., Berger, A., Ramirez, L., Calzadiaz Ramirez, Liliana, Volker Döring, Lindner, S., Dubois, Ivan, Perret, A., Meyer, Sophia, Fouré, M., Bouzon, Madeleine, Erb, Tobias, Marion Fouré, Lindner, Steffen, Stoffel, G., Alain Perret, Berger, Anne, Bar-Even, A., Roche, David, Anne Berger, Fouré, Marion, David Roche, Tobias J. Erb, Bouzon, M., Meyer, S., Gabriele M. M. Stoffel, Roche, D., Perret, Alain, Steffen N. Lindner, Ivan Dubois, Sophia N. Meyer   +38 more
core   +1 more source

Production, characterization and determination of the real catalytic properties of the putative "succinate dehydrogenase" from Wolinella succinogenes

, 2009
Both the genomes of the epsilonproteobacteria Wolinella succinogenes and Campylobacter jejuni contain operons (sdhABE) that encode for so far uncharacterized enzyme complexes annotated as ‘non-classical’ succinate:quinone reductases (SQRs).
Juhnke, Hanno Dominik, Hiltscher, Heiko, Juhnke, H., Schwalbe, H., Hamid R. Nasiri, Lancaster, C. Roy D., Nasiri, Hamid R., Heiko Hiltscher, Schwalbe, Harald, Nasiri, H., Harald Schwalbe, Juhnke, Hanno D., C. Roy D. Lancaster, Nasiri, Hamid Reza, Lancaster, C., Hanno D. Juhnke, Hiltscher, H.   +16 more
core   +1 more source

Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid

, 2020
The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer
Linley Schofield (15394772), Andrew Sutherland-Smith (15394775), Ron Ronimus (5484935), Vince Carbone (15395420), Carrie Sang (254175)   +4 more
core  

Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein bisulfide isomerase

, 2005
We present the first identification of transient folding intermediates of endogenous thyroglobulin (Tg; a large homodimeric secretory glycoprotein of thyrocytes), which include mixed disulfides with endogenous oxidoreductases servicing Tg folding needs ...
Ulianich, Luca, High, Stephen; id_orcid, B. Di Jeso, Arvan, Peter, A. S. Treglia, Treglia, A. Sonia, Y.-n. Park, L. Ulianich, S. High, Urbanas, Malene L., P. Arvan, Park, Young Nam, M. L. Urbanas, Di Jeso, Bruno   +13 more
core   +1 more source

Influence of the pKa value of the buried, active-site cysteine on the redox properties of thioredoxin-like oxidoreductases

, 2000
Thioredoxin constitutes the prototype of the thiol-disulfide oxidoreductase family. These enzymes contain an active-site disulfide bridge with the consensus sequence Cys-Xaa-Xaa-Cys.
Ekkehard Mössner, Iwai, Hideo, Glockshuber, Rudi, Hideo Iwai, Mössner, Ekkehard, Rudi Glockshuber   +5 more
core   +1 more source