Results 201 to 210 of about 41,420 (299)

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, EarlyView.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

Functional Characterization of Enone Oxidoreductase Orthologs Highlights Hidden Furaneol Biosynthetic Capacity in Apples. [PDF]

J Agric Food Chem
Li C, Jahr K, Sun Y, Thalhammer BJ, Schweppe J, Wang X, Hoffmann TD, Hoffmann T, Schwab W.   +8 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

On the emergence of metabolism: the evolution of proteins that powered life. [PDF]

Philos Trans R Soc Lond B Biol Sci
Nanda V, Siess J, Jagilinki BP, Hazen RM, Kamerlin SCL, Koder R, Noy D, Silberg J, Tezcan FA, Ulijn R, Yee N, Falkowski P.   +11 more
europepmc   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Discovery of New Angucyclin(on)e Derivatives and Their Genetic Architecture from <i>Streptomyces</i> sp. SYP-A7185 in the Rhizosphere Soil of <i>Panax notoginseng</i>. [PDF]

ACS Omega
Xue JY, Wang CY, Wu YY, Zhang MY, Li S, Zhou XY, Zhang YX.   +6 more
europepmc   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Draft genome sequence of <i>Petrotoga</i> sp. DB-2, a thermophilic Fe(III)-reducing bacterium isolated from a petroleum reservoir. [PDF]

Microbiol Resour Announc
Abdulwahed L, Greene AC.
europepmc   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Modular control of orchid beauty: co-expression networks orchestrate organ development and evolution in Phalaenopsis flower. [PDF]

Plant Mol Biol
Lucibelli F, Carfora A, Varone M, Volpe G, Di Lillo P, Mazzucchiello SM, Saccone G, Salvemini M, Aceto S.   +8 more
europepmc   +1 more source