Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini +24 more
wiley +1 more source
Remote monitoring of spirometry and oximetry in patients with connective tissue disease related interstitial lung disease: a prospective observational cohort study. [PDF]
Ng WL +7 more
europepmc +1 more source
This Perspective examines practical power solutions for wearable healthcare systems, highlighting the limits of standard batteries. It categorizes wearables into four domains—point‐of‐care diagnostics, episodic monitoring, continuous long‐term monitoring, and therapeutic platforms—and analyzes their power needs.
Seokheun Choi
wiley +1 more source
Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study
Changes in airway dynamics in children with sickle cell anemia after maximal cardiopulmonary exercise testing and a controlled intensity interval excercise challenge. ABSTRACT Sickle cell anemia (SCA) leads to reduced physical functioning and cardiopulmonary fitness. Prior studies suggest that airway hyperresponsiveness to bronchoprovocation testing is
Robyn T. Cohen +9 more
wiley +1 more source
Home Sleep Apnoea Testing: Advances, Challenges and Considerations in Heart Failure. [PDF]
Steinberg R +3 more
europepmc +1 more source
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih +2 more
wiley +1 more source
Inconsistent Pulse Oximetry Signal in Multiple Sites as an Early Indicator of Severe Hypovolemia. [PDF]
Taha M, Malik R, Davis WT, Mohamed S.
europepmc +1 more source
Successful ECPR in Treating a Case of Chlorine Gas Poisoning Leading to ARDS and Cardiac Arrest
ABSTRACT Chlorine gas inhalation represents a rare but devastating toxicological emergency, capable of inducing fulminant acute respiratory distress syndrome (ARDS) and cardiovascular collapse. Extracorporeal cardiopulmonary resuscitation as a salvage therapy for a child who suffered refractory cardiac arrest following severe chlorine gas‐induced ARDS ...
Wu Ge +7 more
wiley +1 more source
Role of Cerebral Oximetry in Reducing Postoperative End-Organ Dysfunction After Major Non-Cardiac Surgery: A Randomised Controlled Trial. [PDF]
Bieze M +6 more
europepmc +1 more source

